Brunel University Research Archive(BURA) preserves and enables easy and open access to all
types of digital content. It showcases Brunel's research outputs.
Research contained within BURA is open access, although some publications may be subject
to publisher imposed embargoes. All awarded PhD theses are also archived on BURA.
Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/27673| Title: | Genetic risk for alzheimer’s disease, cognition, and mild behavioral impairment in healthy older adults |
| Authors: | Creese, B Arathimos, R Brooker, H Aarsland, D Corbett, A Lewis, C Ballard, C Ismail, Z |
| Keywords: | Alzheimer's disease;cognition;mild behavioral impairment;neuropsychiatric symptoms;polygenic score |
| Issue Date: | 26-Jan-2021 |
| Publisher: | Wiley on behalf of Alzheimer's Association |
| Citation: | Creese, B. et al. (2021) 'Genetic risk for alzheimer’s disease, cognition, and mild behavioral impairment in healthy older adults', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13 (1), e12164, pp. 1 - 10. doi: 10.1002/dad2.12164. |
| Abstract: | Copyright © 2021 The Authors. Background: The neuropsychiatric syndrome mild behavioral impairment (MBI) describes an at-risk state for dementia and may be a useful screening tool for sample enrichment. We hypothesized that stratifying a cognitively normal sample on MBI status would enhance the association between genetic risk for Alzheimer's disease (AD) and cognition. Methods: Data from 4458 participants over age 50 without dementia was analyzed. A cognitive composite score was constructed and the MBI Checklist was used to stratify those with MBI and those without. Polygenic scores for AD were generated using summary statistics from the IGAP study. Results: AD genetic risk was associated with worse cognition in the MBI group but not in the no MBI group (MBI: β = –0.09, 95% confidence interval: –0.13 to –0.03, P = 0.002, R2 = 0.003). The strongest association was in those with more severe MBI aged ≥65. Conclusions: MBI is an important feature of aging; screening on MBI may be a useful sample enrichment strategy for clinical research. |
| URI: | https://bura.brunel.ac.uk/handle/2438/27673 |
| DOI: | https://doi.org/10.1002/dad2.12164 |
| Other Identifiers: | ORCID iD: Byron Creese https://orcid.org/0000-0001-6490-6037 e12164 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | 933.3 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License
