1. Brunel University Research Archive
  2. College of Health, Medicine and Life Sciences
  3. Dept of Life Sciences
  4. Dept of Life Sciences Research Papers
Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/27673
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCreese, B-
dc.contributor.authorArathimos, R-
dc.contributor.authorBrooker, H-
dc.contributor.authorAarsland, D-
dc.contributor.authorCorbett, A-
dc.contributor.authorLewis, C-
dc.contributor.authorBallard, C-
dc.contributor.authorIsmail, Z-
dc.date.accessioned2023-11-19T18:36:53Z-
dc.date.available2023-11-19T18:36:53Z-
dc.date.issued2021-01-26-
dc.identifierORCID iD: Byron Creese https://orcid.org/0000-0001-6490-6037-
dc.identifiere12164-
dc.identifier.citationCreese, B. et al. (2021) 'Genetic risk for alzheimer’s disease, cognition, and mild behavioral impairment in healthy older adults', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13 (1), e12164, pp. 1 - 10. doi: 10.1002/dad2.12164.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/27673-
dc.description.abstractCopyright © 2021 The Authors. Background: The neuropsychiatric syndrome mild behavioral impairment (MBI) describes an at-risk state for dementia and may be a useful screening tool for sample enrichment. We hypothesized that stratifying a cognitively normal sample on MBI status would enhance the association between genetic risk for Alzheimer's disease (AD) and cognition. Methods: Data from 4458 participants over age 50 without dementia was analyzed. A cognitive composite score was constructed and the MBI Checklist was used to stratify those with MBI and those without. Polygenic scores for AD were generated using summary statistics from the IGAP study. Results: AD genetic risk was associated with worse cognition in the MBI group but not in the no MBI group (MBI: β = –0.09, 95% confidence interval: –0.13 to –0.03, P = 0.002, R2 = 0.003). The strongest association was in those with more severe MBI aged ≥65. Conclusions: MBI is an important feature of aging; screening on MBI may be a useful sample enrichment strategy for clinical research.en_US
dc.description.sponsorshipThis work was funded in part through the MRC Proximity to Discovery: Industry Engagement Fund (External Collaboration, Innovation and Entrepreneurism: Translational Medicine in Exeter 2 (EXCITEME2) ref. MC_PC_17189) awarded to Dr Creese and MRC grant MR/N015746/1 awarded to Prof Lewis. The addition of the family history of dementia questionnaire to the PROTECT study was supported by a small grant from the Alzheimer's Research UK South West Network. This article represents independent research part funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London.en_US
dc.format.extent1 - 10-
dc.format.mediumEelctronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherWiley on behalf of Alzheimer's Associationen_US
dc.rightsCopyright © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAlzheimer's diseaseen_US
dc.subjectcognitionen_US
dc.subjectmild behavioral impairmenten_US
dc.subjectneuropsychiatric symptomsen_US
dc.subjectpolygenic scoreen_US
dc.titleGenetic risk for alzheimer’s disease, cognition, and mild behavioral impairment in healthy older adultsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1002/dad2.12164-
dc.relation.isPartOfAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring-
pubs.issue1-
pubs.publication-statusPublished-
pubs.volume13-
dc.identifier.eissn2352-8729-
dc.rights.holderThe Authors-
Appears in Collections:Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
FullText.pdfCopyright © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.933.3 kBAdobe PDFView/Open
Show simple item record


This item is licensed under a Creative Commons License Creative Commons