Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects?

Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/24499

Title:	Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects?
Authors:	Kortenkamp, A
Issue Date:	8-Apr-2022
Publisher:	National Institute of Environmental Health Sciences (NIEHS)
Citation:	Kortenkamp, A. (2022) ‘Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects?’, Environmental Health Perspectives. Environmental Health Perspectives. doi:10.1289/ehp11051.
Abstract:	Distinguishing chemical mixtures in terms of the similarity vs. dissimilarity of their components’ mechanisms or modes of action (MOAs) is perceived as a key issue in mixture risk assessment. However, the well-designed study by Van der Ven et al.1 of a mixture of chemicals producing craniofacial malformations in zebra fish embryos calls the relevance of such distinctions into question
Description:	This article is a companion of: Van Der Ven, L.T.M. et al. (2022) ‘Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action’, Environmental Health Perspectives. Environmental Health Perspectives. doi:10.1289/ehp9888.
URI:	http://bura.brunel.ac.uk/handle/2438/24499
DOI:	http://dx.doi.org/10.1289/EHP11051
ISSN:	0091-6765 1552-9924
Appears in Collections:	Dept of Life Sciences Research Papers

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