Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/23290
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rehman, S | - |
dc.contributor.author | Ravinayagam, V | - |
dc.contributor.author | Nahvi, I | - |
dc.contributor.author | Aldossary, H | - |
dc.contributor.author | Al-Shammari, M | - |
dc.contributor.author | Amiri, MSA | - |
dc.contributor.author | Kishore, U | - |
dc.contributor.author | Al-Suhaimi, EA | - |
dc.date.accessioned | 2021-09-29T11:55:39Z | - |
dc.date.available | 2021-09-29T11:55:39Z | - |
dc.date.issued | 2021-08-18 | - |
dc.identifier.citation | Rehman S, Ravinayagam V, Nahvi I, Aldossary H, Al-Shammari M, Amiri MSA, Kishore U and Al-Suhaimi EA (2021) Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women. Front. Immunol. 12:680845. doi: 10.3389/fimmu.2021.680845 | en_US |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/23290 | - |
dc.description.abstract | The current coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), has resulted in a major global pandemic, causing extreme morbidity and mortality. Few studies appear to suggest a significant impact of gender in morbidity and mortality, where men are reported at a higher risk than women. The infectivity, transmissibility, and varying degree of disease manifestation (mild, modest, and severe) in population studies reinforce the importance of a number of genetic and epigenetic factors, in the context of immune response and gender. The present review dwells on several contributing factors such as a stronger innate immune response, estrogen, angiotensin-converting enzyme 2 gene, and microbiota, which impart greater resistance to the SARS-CoV-2 infection and disease progression in women. In addition, the underlying importance of associated microbiota and certain environmental factors in gender-based disparity pertaining to the mortality and morbidity due to COVID-19 in women has also been addressed. | en_US |
dc.description.sponsorship | Institute for Research and Medical Consultation | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media SA | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Environment | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Immunity | en_US |
dc.subject | Gender | en_US |
dc.subject | Hormones | en_US |
dc.subject | Microbiota | en_US |
dc.title | Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.3389/fimmu.2021.680845 | - |
dc.relation.isPartOf | Frontiers in Immunology | - |
pubs.publication-status | Published | - |
pubs.volume | 12 | - |
dc.identifier.eissn | 1664-3224 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 12.17 MB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.