Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/9913
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBailey, SJ-
dc.contributor.authorRomer, LM-
dc.contributor.authorJelly, J-
dc.contributor.authorWilkerson, DP-
dc.contributor.authorDiMenna, FJ-
dc.contributor.authorJones, AM-
dc.date.accessioned2015-01-22T14:49:21Z-
dc.date.available2010-05-27-
dc.date.available2015-01-22T14:49:21Z-
dc.date.issued2010-
dc.identifier.citationJournal of Applied Physiology, 109:2, pp. 457 - 468, 2010en_US
dc.identifier.issn8750-7587-
dc.identifier.urihttp://jap.physiology.org/content/109/2/457-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/9913-
dc.description.abstractFatigue of the respiratory muscles during intense exercise might compromise leg blood flow, thereby constraining oxygen uptake (VO2) and limiting exercise tolerance. We tested the hypothesis that inspiratory muscle training (IMT) would reduce inspiratory muscle fatigue, speed VO2 kinetics and enhance exercise tolerance. Sixteen recreationally active subjects (mean ± SD, age 22 ± 4 yr) were randomly assigned to receive 4 wk of either pressure threshold IMT [30 breaths twice daily at ~50% of maximum inspiratory pressure (MIP)] or sham treatment (60 breaths once daily at ~15% of MIP). The subjects completed moderate-, severe- and maximal-intensity "step" exercise transitions on a cycle ergometer before (Pre) and after (Post) the 4-wk intervention period for determination of VO2 kinetics and exercise tolerance. There were no significant changes in the physiological variables of interest after Sham. After IMT, baseline MIP was significantly increased (Pre vs. Post: 155 ± 22 vs. 181 ± 21 cmH2O; P < 0.001), and the degree of inspiratory muscle fatigue was reduced after severe- and maximal-intensity exercise. During severe exercise, the VO2 slow component was reduced (Pre vs. Post: 0.60 ± 0.20 vs. 0.53 ± 0.24 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 765 ± 249 vs. 1,061 ± 304 s; P < 0.01). Similarly, during maximal exercise, the VO2 slow component was reduced (Pre vs. Post: 0.28 ± 0.14 vs. 0.18 ± 0.07 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 177 ± 24 vs. 208 ± 37 s; P < 0.01). Four weeks of IMT, which reduced inspiratory muscle fatigue, resulted in a reduced VO2 slow-component amplitude and an improved exercise tolerance during severe- and maximal-intensity exercise. The results indicate that the enhanced exercise tolerance observed after IMT might be related, at least in part, to improved VO2 dynamics, presumably as a consequence of increased blood flow to the exercising limbs.en_US
dc.format.extent457 - 468-
dc.format.extent457 - 468-
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.isreplacedby2438/10116-
dc.relation.isreplacedbyhttp://bura.brunel.ac.uk/handle/2438/10116-
dc.subjectFatigueen_US
dc.subjectRespiratory musclesen_US
dc.subjectIntense exerciseen_US
dc.titleInspiratory muscle training enhances pulmonary O2 uptake kinetics and high-intensity exercise tolerance in humansen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1152/japplphysiol.00077.2010-
dc.relation.isPartOfJournal of Applied Physiology-
dc.relation.isPartOfJournal of Applied Physiology-
pubs.issue2-
pubs.issue2-
pubs.volume109-
pubs.volume109-
pubs.organisational-data/Brunel-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences-
pubs.organisational-data/Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Sport-
pubs.organisational-data/Brunel/University Research Centres and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies-
pubs.organisational-data/Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology-
Appears in Collections:Sport
Dept of Life Sciences Research Papers

Files in This Item:
File Description SizeFormat 
Notice.pdf44.97 kBAdobe PDFView/Open


Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.