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DC Field | Value | Language |
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dc.contributor.author | Armstrong-James, DP | - |
dc.contributor.author | Turnbull, SA | - |
dc.contributor.author | Teo, I | - |
dc.contributor.author | Stark, J | - |
dc.contributor.author | Rogers, NJ | - |
dc.contributor.author | Rogers, TRF | - |
dc.contributor.author | Bignell, E | - |
dc.contributor.author | Haynes, K | - |
dc.date.accessioned | 2014-08-04T15:37:07Z | - |
dc.date.available | 2014-08-04T15:37:07Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | The Journal of Infectious Diseases, 200(8), 1341-1351, 2009 | en_US |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | http://jid.oxfordjournals.org/content/200/8/1341 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/8828 | - |
dc.description | This article is available open access through the publisher’s website. Copyright @ 2009 Oxford University Press. | en_US |
dc.description.abstract | Background - Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world. Historically, susceptibility to IA has been associated with prolonged neutropenia; however, IA has now become a major problem in patients on calcineurin inhibitors and allogenic hematopoetic stem cell transplant patients following engraftment. These observations suggest complex cellular mechanisms govern immunity to IA. Methods - To characterize the key early events that govern outcome from infection with Aspergillus fumigatus we performed a comparative immunochip microarray analysis of the pulmonary transcriptional response to IA between cyclophosphamide-treated mice and immunocompetent mice at 24 h after infection. Results - We demonstrate that death due to infection is associated with a failure to generate an incremental interferon-γ response, increased levels of interleukin-5 and interleukin-17a transcript, coordinated expression of a network of tumor necrosis factor–α-related genes, and increased levels of tumor necrosis factor–α. In contrast, clearance of infection is associated with increased expression of a number genes encoding proteins involved in innate pathogen clearance, as well as apoptosis and control of inflammation. Conclusion - This first organ-level immune response transcriptional analysis for IA has enabled us to gain new insights into the mechanisms that govern fungal immunity in the lung. | en_US |
dc.description.sponsorship | The BBSRC, CGD Research Trust, and the MRC. | en_US |
dc.language | eng | - |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.subject | Invasive aspergillosis | en_US |
dc.subject | Fungal infection | en_US |
dc.subject | Tumor necrosis | en_US |
dc.subject | Calcineurin inhibitors | en_US |
dc.subject | Allogenic hematopoetic stem cell transplant | en_US |
dc.title | Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1086/605931 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
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Notice.pdf | 44.95 kB | Adobe PDF | View/Open |
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