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http://bura.brunel.ac.uk/handle/2438/8824
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DC Field | Value | Language |
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dc.contributor.author | Malhas, A | - |
dc.contributor.author | Saunders, NJ | - |
dc.contributor.author | Vaux, DJ | - |
dc.date.accessioned | 2014-08-04T13:45:20Z | - |
dc.date.available | 2014-08-04T13:45:20Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Cell Cycle, 9(3), 531-539, 2010 | en_US |
dc.identifier.issn | 1538-4101 | - |
dc.identifier.uri | https://www.landesbioscience.com/journals/cc/article/10511/ | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/8824 | - |
dc.description | This article is available open access through the publisher’s website. Copyright @ 2010 Landes Bioscience. | en_US |
dc.description.abstract | The nuclear envelope can regulate gene expression through its interaction with chromatin and by the sequestration of specific transcription factors. In this study, we show that such regulation can be achieved via microRNA regulation. We identify a set of miRNAs that are dysregulated in the absence of a fully functional nuclear lamina. We then focus on miRNA-31 and experimentally confirm its targets. The target set identified is significantly enriched in genes involved in controlling progress through the cell cycle such as Cdkn2a. Normalizing miRNA-31 levels, either using a specific inhibitor or by restoration of the nuclear lamina, also normalizes cell cycle distribution and cell proliferation rates. We show that the 3’UTR of p16Ink4a/p19Arf has a functional miRNA-31 binding site which contributes to the observed regulation of cell cycle progression. Our findings are the first demonstration that the nuclear envelope can control gene expression by regulating specific miRNA levels, and that miRNA-31 is involved in the regulation of cell proliferation and progress through the cell cycle at least in part by regulating the levels of p16Ink4a/p19Arf. | en_US |
dc.description.sponsorship | The EPA Trust and the MRC. | en_US |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | Landes Bioscience | en_US |
dc.subject | Oct-1 | en_US |
dc.subject | MicroRNA-31 | en_US |
dc.subject | Lamin B1 | en_US |
dc.subject | Tumorigenesis | en_US |
dc.subject | Nuclear lamina | en_US |
dc.title | The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.4161/cc.9.3.10511 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Health and Life Sciences/Dept of Life Sciences/Biological Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Synthetic Biology | - |
pubs.organisational-data | /Brunel/Group Publication Pages | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
Appears in Collections: | Biological Sciences Dept of Life Sciences Research Papers |
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