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DC Field | Value | Language |
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dc.contributor.author | Bach, DR | - |
dc.contributor.author | Behrens, TE | - |
dc.contributor.author | Garrido, L | - |
dc.contributor.author | Weiskopf, N | - |
dc.contributor.author | Dolan, RJ | - |
dc.date.accessioned | 2014-04-15T15:58:55Z | - |
dc.date.available | 2014-04-15T15:58:55Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Journal of Neuroscience, 31(2), 618 - 623, 2011 | en_US |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://www.jneurosci.org/content/31/2/618 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/8325 | - |
dc.description | Copyright © 2011 Society for Neuroscience and the authors. The The Journal of Neuroscience uses a Creative Commons Attribution-NonCommercial-ShareAlike licence: http://creativecommons.org/licenses/by-nc-sa/4.0/. | en_US |
dc.description.abstract | Despite a homogenous macroscopic appearance on magnetic resonance images, subregions of the amygdala express distinct functional profiles as well as corresponding differences in connectivity. In particular, histological analysis shows stronger connections for superficial (i.e., centromedial and cortical), compared with deep (i.e., basolateral and other), amygdala nuclei to lateral orbitofrontal cortex and stronger connections of deep compared with superficial, nuclei to polymodal areas in the temporal pole. Here, we use diffusion weighted imaging with probabilistic tractography to investigate these connections in humans. We use a data-driven approach to segment the amygdala into two subregions using k-means clustering. The identified subregions are spatially contiguous and their location corresponds to deep and superficial nuclear groups. Quantification of the connection strength between these amygdala clusters and individual target regions corresponds to qualitative histological findings in non-human primates, indicating such findings can be extrapolated to humans. We propose that connectivity profiles provide a potentially powerful approach for in vivo amygdala parcellation and can serve as a guide in studies that exploit functional and anatomical neuroimaging. | en_US |
dc.description.sponsorship | The Wellcome Trust, a Max Planck Research Award and Swiss National Science Foundation. | en_US |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | Society for Neuroscience | en_US |
dc.subject | Amygdala nuclei | en_US |
dc.subject | Probabilistic tractography | en_US |
dc.subject | Anatomical neuroimaging | en_US |
dc.subject | Diffusion weighted imaging | en_US |
dc.title | Deep and superficial amygdala nuclei projections revealed in vivo by probabilistic tractography | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1523/JNEUROSCI.2744-10.2011 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Social Sciences | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/School of Social Sciences/Psychology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/Brunel Business School - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/Brunel Business School - URCs and Groups/Centre for Research into Entrepreneurship, International Business and Innovation in Emerging Markets | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Arts - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Arts - URCs and Groups/Brunel Centre for Contemporary Writing | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute for Ageing Studies | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Brunel Institute of Cancer Genetics and Pharmacogenomics | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Information Systems, Computing and Mathematics - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Information Systems, Computing and Mathematics - URCs and Groups/Multidisclipary Assessment of Technology Centre for Healthcare (MATCH) | - |
Appears in Collections: | Publications Psychology Dept of Life Sciences Research Papers |
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