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http://bura.brunel.ac.uk/handle/2438/6670
Title: | Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides |
Authors: | Benner, MF Ballabio, E van Kester, MS Saunders, NJ Vermeer, MH Willemze, R Lawrie, CH Tensen, CP |
Keywords: | miR-155;miRNA microarray;Mycosis fungoides;Primary cutaneous anaplastic large cell lymphoma;Q-PCR |
Issue Date: | 2012 |
Publisher: | John Wiley and Sons |
Citation: | Experimental Dermatology, 21(8): 632 - 634, Aug 2012 |
Abstract: | The miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory dermatoses (BID) as previously used to study the miRNA expression profile of tumor-stage mycosis fungoides (MF). We identified 13 differentially expressed miRNAs between C-ALCL and BID. The up-regulation of miR-155, miR-27b, miR-30c and miR-29b in C-ALCL was validated by miRNA-Q-PCR on independent study groups. Additionally, the miRNA expression profiles of C-ALCL were compared with those of tumor-stage MF. Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL. This study, the first describing the miRNA expression profile of C-ALCL, reveals differences with tumor-stage MF, suggesting a different contribution to the pathogenesis of these lymphomas. |
Description: | Copyright @ 2012 John Wiley & Sons |
URI: | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2012.01548.x/abstract http://bura.brunel.ac.uk/handle/2438/6670 |
DOI: | http://dx.doi.org/10.1111/j.1600-0625.2012.01548.x |
ISSN: | 0906-6705 |
Appears in Collections: | Biological Sciences Publications Dept of Life Sciences Research Papers |
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