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http://bura.brunel.ac.uk/handle/2438/28495| Title: | Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics |
| Authors: | Gerke, V Gavins, FNE Geisow, M Grewal, T Jaiswal, JK Nylandsted, J Rescher, U |
| Keywords: | calcium;cell biology;drug discovery;membrane lipids |
| Issue Date: | 21-Feb-2024 |
| Publisher: | Springer Nature |
| Citation: | Gerke, V. et al. (2024) 'Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics', Nature communications, 15 (1), 1574, pp. 1 - 15. doi: 10.1038/s41467-024-45954-0. |
| Abstract: | Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca2+-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field. |
| URI: | https://bura.brunel.ac.uk/handle/2438/28495 |
| DOI: | https://doi.org/10.1038/s41467-024-45954-0 |
| Other Identifiers: | ORCiD: Volker Gerke https://orcid.org/0000-0001-7208-8206 1574 ORCiD: Felicity N. E. Gavins https://orcid.org/0000-0001-7008-5423 ORCiD: Michael Geisow https://orcid.org/0009-0001-6218-8200 ORCiD: Thomas Grewal https://orcid.org/0000-0002-7937-8887 ORCiD: Jyoti K. Jaiswal https://orcid.org/0000-0002-5992-5185 ORCiD: Jesper Nylandsted https://orcid.org/0000-0001-6474-5093 ORCiD: Ursula Rescher https://orcid.org/0000-0001-8892-319X 1574 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
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