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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/27687
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dc.contributor.authorUllgren, A-
dc.contributor.authorÖijerstedt, L-
dc.contributor.authorOlofsson, J-
dc.contributor.authorBergström, S-
dc.contributor.authorRemnestål, J-
dc.contributor.authorvan Swieten, JC-
dc.contributor.authorJiskoot, LC-
dc.contributor.authorSeelaar, H-
dc.contributor.authorBorroni, B-
dc.contributor.authorSanchez-Valle, R-
dc.contributor.authorMoreno, F-
dc.contributor.authorThonberg, H-
dc.contributor.authorSogorb-Esteve, A-
dc.contributor.authorTimberlake, C-
dc.contributor.authorTodd, E-
dc.contributor.authorSantana, I-
dc.contributor.authorVan Damme, P-
dc.contributor.authorVandenbulcke, M-
dc.contributor.authorVeldsman, M-
dc.contributor.authorGalimberti, D-
dc.contributor.authorVerdelho, A-
dc.contributor.authorAnderl-Straub, S-
dc.contributor.authorVillanua, J-
dc.contributor.authorWarren, J-
dc.contributor.authorConvery, R-
dc.contributor.authorWilke, C-
dc.contributor.authorWoollacott, I-
dc.contributor.authorZetterberg, H-
dc.contributor.authorDucharme, S-
dc.contributor.authorZulaica, M-
dc.contributor.authorDurães, J-
dc.contributor.authorLima, M-
dc.contributor.authorFumagalli, G-
dc.contributor.authorLemos, J-
dc.contributor.authorRowe, JB-
dc.contributor.authorMasellis, M-
dc.contributor.authorHeller, C-
dc.contributor.authorTartaglia, MC-
dc.contributor.authorFinger, E-
dc.contributor.authorVandenberghe, R-
dc.contributor.authorde Mendonça, A-
dc.contributor.authorButler, CR-
dc.contributor.authorGerhard, A-
dc.contributor.authorAndersson, C-
dc.contributor.authorOtto, M-
dc.contributor.authorBouzigues, A-
dc.contributor.authorRussell, L-
dc.contributor.authorSwift, IJ-
dc.contributor.authorRohrer, JD-
dc.contributor.authorMånberg, A-
dc.contributor.authorNilsson, P-
dc.contributor.authorGraff, C-
dc.contributor.authorAfonso, S-
dc.contributor.authorAlmeida, MR-
dc.contributor.authorAntonell, A-
dc.contributor.authorCope, T-
dc.contributor.authorArighi, A-
dc.contributor.authorBalasa, M-
dc.contributor.authorBarandiaran, M-
dc.contributor.authorBargalló, N-
dc.contributor.authorBartha, R-
dc.contributor.authorGreaves, C-
dc.contributor.authorBender, B-
dc.contributor.authorBuratti, E-
dc.contributor.authorPeakman, G-
dc.contributor.authorBenussi, L-
dc.contributor.authorBertoux, M-
dc.contributor.authorBinetti, G-
dc.contributor.authorDeramecourt, V-
dc.contributor.authorBlack, S-
dc.contributor.authorBocchetta, M-
dc.contributor.authorBorrego-Ecija, S-
dc.contributor.authorRogaeva, E-
dc.contributor.authorBras, J-
dc.contributor.authorBruffaerts, R-
dc.contributor.authorCañada, M-
dc.contributor.authorFunkiewiez, A-
dc.contributor.authorCantoni, V-
dc.contributor.authorCaroppo, P-
dc.contributor.authorCash, D-
dc.contributor.authorCastelo-Branco, M-
dc.contributor.authorDi Fede, G-
dc.contributor.authorDíez, A-
dc.contributor.authorGuerreiro, R-
dc.contributor.authorFenoglio, C-
dc.contributor.authorFerreira, CB-
dc.contributor.authorFox, N-
dc.contributor.authorFreedman, M-
dc.contributor.authorGabilondo, A-
dc.contributor.authorGasparotti, R-
dc.contributor.authorGauthier, S-
dc.contributor.authorAlberici, A-
dc.contributor.authorGiaccone, G-
dc.contributor.authorGorostidi, A-
dc.contributor.authorIndakoetxea, B-
dc.contributor.authorPievani, M-
dc.contributor.authorJelic, V-
dc.contributor.authorKarnath, H-O-
dc.contributor.authorKeren, R-
dc.contributor.authorKuchcinski, G-
dc.contributor.authorLangheinrich, T-
dc.contributor.authorShoesmith, C-
dc.contributor.authorLebouvier, T-
dc.contributor.authorLeitão, MJ-
dc.contributor.authorLaforce, R-
dc.contributor.authorLladó, A-
dc.contributor.authorMaruta, C-
dc.contributor.authorMeeter, L-
dc.contributor.authorPijnenburg, Y-
dc.contributor.authorMiltenberger, G-
dc.contributor.authorvan Minkelen, R-
dc.contributor.authorMitchell, S-
dc.contributor.authorTirabosch, P-
dc.contributor.authorMoore, K-
dc.contributor.authorNicholas, J-
dc.contributor.authorOlives, J-
dc.contributor.authorRollin, A-
dc.contributor.authorOurselin, S-
dc.contributor.authorPadovani, A-
dc.contributor.authorPanman, J-
dc.contributor.authorPapma, JM-
dc.contributor.authorPremi, E-
dc.contributor.authorPrioni, S-
dc.contributor.authorTábuas-Pereira, M-
dc.contributor.authorRademakers, R-
dc.contributor.authorRedaelli, V-
dc.contributor.authorRinaldi, D-
dc.contributor.authorRittman, T-
dc.contributor.authorRosa-Neto, P-
dc.contributor.authorRossi, G-
dc.contributor.authorRosser, M-
dc.contributor.authorScarpini, E-
dc.contributor.authorSemler, E-
dc.contributor.authorShafei, R-
dc.contributor.authorTainta, M-
dc.contributor.authorSynofzik, M-
dc.contributor.authorTaipa, R-
dc.contributor.authorTang-Wai, D-
dc.contributor.authorThomas, DL-
dc.contributor.authorThompson, P-
dc.contributor.otherGenetic Frontotemporal Dementia Initiative (GENFI)-
dc.date.accessioned2023-11-20T23:47:37Z-
dc.date.available2023-11-20T23:47:37Z-
dc.date.issued2023-11-15-
dc.identifierORCID iD: Caroline Graff https://orcid.org/0000-0002-9949-2951-
dc.identifierORCID iD: Martina Bocchetta https://orcid.org/0000-0003-1814-5024-
dc.identifier85-
dc.identifier.citationUllgren, A. et al. on behalf of the Genetic Frontotemporal Dementia Initiative (GENFI) (2023) 'Altered plasma protein profiles in genetic FTD – a GENFI study', Molecular Neurodegeneration, 18 (1), 85, pp. 1 - 12. doi: 10.1186/s13024-023-00677-6.en_US
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/27687-
dc.descriptionAvailability of data and materials: Anonymized data may be shared upon request from a qualified academic investigator for the purpose of replication of the results and procedures detailed in this article. All requests must be in agreement with EU legislation on general data protection and must be in line with the decisions from the Ethical Review Board of Sweden. Data sharing should be regulated in a material transfer agreement and/or data processing agreement as appropriate.en_US
dc.descriptionSupplementary Information is available online at: https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00677-6#Sec16 .-
dc.description.abstractCopyright © The Author(s) 2023. Background: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. Results: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. Conclusion: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process.en_US
dc.description.sponsorshipOpen access funding provided by Karolinska Institute. C.G. received funding from EU Joint Programme—Neurodegenerative Disease Research -Prefrontals Vetenskapsrådet Dnr 529–2014-7504, Vetenskapsrådet 2015–02926, Vetenskapsrådet 2018–02754, the Swedish FTD Inititative-Schörling Foundation, Alzheimer Foundation, Brain Foundation, Dementia Foundation and Region Stockholm ALF-project. PN received funding from KTH Center for Applied Precision Medicine (KCAP) funded by the Erling-Persson Family Foundation, the Swedish FTD Inititative-Schörling Foundation and Åhlén foundation. D.G. received support from the EU Joint Programme—Neurodegenerative Disease Research and the Italian Ministry of Health (PreFrontALS) grant 733051042. E.F. has received funding from a Canadian Institute of Health Research grant #327387. F.M. received funding from the Tau Consortium and the Center for Networked Biomedical Research on Neurodegenerative Disease. J.B.R. has received funding from the Welcome Trust (103838) and is supported by the Cambridge University Centre for Frontotemporal Dementia, the Medical Research Council (SUAG/051 G101400) and the National Institute for Health Research Cambridge Biomedical Research Centre (BRC-1215–20014). J.C.V.S. was supported by the Dioraphte Foundation grant 09–02-03–00, Association for Frontotemporal Dementias Research Grant 2009, Netherlands Organization for Scientific Research grant HCMI 056–13-018, ZonMw Memorabel (Deltaplan Dementie, project number 733 051 042), Alzheimer Nederland and the Bluefield Project. J.D.R. is supported by the Bluefield Project and the National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and a Miriam Marks Brain Research UK Senior Fellowship. M.M. has received funding from a Canadian Institute of Health Research operating grant and the Weston Brain Institute and Ontario Brain Institute. M.O. has received funding from Germany’s Federal Ministry of Education and Research (BMBF). R.S-V. is supported by Alzheimer’s Research UK Clinical Research Training Fellowship (ARUK-CRF2017B-2) and has received funding from Fundació Marató de TV3, Spain (grant no. 20143810). R.V. has received funding from the Mady Browaeys Fund for Research into Frontotemporal Dementia. This work was also supported by the EU Joint Programme—Neurodegenerative Disease Research GENFI-PROX grant [2019–02248; to J.D.R., M.O., B.B., C.G., J.C.V.S. and M.S.en_US
dc.format.extent1 - 12-
dc.format.mediumElectronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherBioMed Central (part of Springer Nature)en_US
dc.rightsCopyright © The Author(s) 2023. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectfrontotemporal dementiaen_US
dc.subjectplasma biomarkersen_US
dc.subjectGRNen_US
dc.subjectC9orf72en_US
dc.subjectMAPTen_US
dc.subjectneurodegenerationen_US
dc.titleAltered plasma protein profiles in genetic FTD – a GENFI studyen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1186/s13024-023-00677-6-
dc.relation.isPartOfMolecular Neurodegeneration-
pubs.issue1-
pubs.publication-statusPublished online-
pubs.volume18-
dc.identifier.eissn1750-1326-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Life Sciences Research Papers

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