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DC Field | Value | Language |
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dc.contributor.author | Heald, AH | - |
dc.contributor.author | Martin, S | - |
dc.contributor.author | Fachim, H | - |
dc.contributor.author | Green, HD | - |
dc.contributor.author | Young, KG | - |
dc.contributor.author | Malipatil, N | - |
dc.contributor.author | Siddals, K | - |
dc.contributor.author | Cortes, G | - |
dc.contributor.author | Tyrrell, J | - |
dc.contributor.author | Wood, AR | - |
dc.contributor.author | Beaumont, RN | - |
dc.contributor.author | Frayling, TM | - |
dc.contributor.author | Donn, R | - |
dc.contributor.author | Narayanan, RP | - |
dc.contributor.author | Ollier, W | - |
dc.contributor.author | Gibson, M | - |
dc.contributor.author | Yaghootkar, H | - |
dc.date.accessioned | 2022-10-27T12:43:31Z | - |
dc.date.available | 2022-10-27T12:43:31Z | - |
dc.date.issued | 2021-01-27 | - |
dc.identifier | e14531 | - |
dc.identifier | ORCiD ID: Hanieh Yaghootkar - https://orcid.org/0000-0001-9672-9477. | - |
dc.identifier.citation | Heald, A.H. et al. (2021) 'Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile', Diabetic Medicine, 38 (9), e14531, pp. 1 - 11. doi: 10.1111/dme.14531 | en_US |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/25387 | - |
dc.description | Data availability statement: We used patient-level data which was fully anonymised prior to analysis. Any requests for access to the Salford data should be made to Dr Adrian Heald. | en_US |
dc.description.abstract | Copyright © 2021 The Authors. Aims Change in weight, HbA1c, lipids, blood pressure and cardiometabolic events over time is variable in individuals with type 2 diabetes. We hypothesised that people with a genetic predisposition to a more favourable adiposity distribution could have a less severe clinical course/progression. Methods We involved people with type 2 diabetes from two UK-based cohorts: 11,914 individuals with GP follow-up data from the UK Biobank and 723 from Salford. We generated a ‘favourable adiposity’ genetic score and conducted cross-sectional and longitudinal studies to test its association with weight, BMI, lipids, blood pressure, medication use and risk of myocardial infarction and stroke using 15 follow-up time points with 1-year intervals. Results The ‘favourable adiposity’ genetic score was cross-sectionally associated with higher weight (effect size per 1 standard deviation higher genetic score: 0.91 kg [0.59,1.23]) and BMI (0.30 kg/m2 [0.19,0.40]), but higher high-density lipoprotein (0.02 mmol/L [0.01,0.02]) and lower triglycerides (−0.04 mmol/L [−0.07, −0.02]) in the UK Biobank at baseline, and this pattern of association was consistent across follow-up. There was a trend for participants with higher ‘favourable adiposity’ genetic score to have lower risk of myocardial infarction and/or stroke (odds ratio 0.79 [0.62, 1.00]) compared to those with lower score. A one standard deviation higher score was associated with lower odds of using lipid-lowering (0.91 [0.86, 0.97]) and anti-hypertensive medication (0.95 [0.91, 0.99]). Conclusions In individuals with type 2 diabetes, having more ‘favourable adiposity’ alleles is associated with a marginally better lipid profile long-term and having lower odds of requiring lipid-lowering or anti-hypertensive medication in spite of relatively higher adiposity. | en_US |
dc.description.sponsorship | Diabetes UK. Grant Number: 17/0005594; European Research Council. Grant Number: 323195. | en_US |
dc.format.extent | 1 - 11 | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | John Wiley & Sons Ltd on behalf of Diabetes UK | en_US |
dc.rights | Copyright © 2021 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | BMI | en_US |
dc.subject | ectopic fat | en_US |
dc.subject | favourable adiposity genetic score | en_US |
dc.subject | HbA1c | en_US |
dc.subject | metabolic profile | en_US |
dc.subject | myocardial infarction | en_US |
dc.subject | stroke | en_US |
dc.subject | type 2 diabetes | en_US |
dc.title | Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1111/dme.14531 | - |
dc.relation.isPartOf | Diabetic Medicine | - |
pubs.issue | 9 | - |
pubs.publication-status | Published | - |
pubs.volume | 38 | - |
dc.identifier.eissn | 1464-5491 | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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