Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/24292
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yasmin, H | - |
dc.contributor.author | Adhikary, A | - |
dc.contributor.author | Al-Ahdal, MN | - |
dc.contributor.author | Roy, S | - |
dc.contributor.author | Kishore, U | - |
dc.date.accessioned | 2022-03-19T09:49:08Z | - |
dc.date.available | 2022-03-19T09:49:08Z | - |
dc.date.issued | 2022-03-09 | - |
dc.identifier.citation | Yasmin, H., Adhikary A., Al-Ahdal, M.N., Roy, S. and Kishore, U. (2022) ‘Host–Pathogen Interaction in Leishmaniasis: Immune Response and Vaccination Strategies’, Immuno, 2 (1), pp. 218–254. doi: 10.3390/immuno2010015. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/24292 | - |
dc.description.abstract | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic life cycle involving a mammalian host and an insect vector. Leishmaniasisis is a worldwide public health problem falling under the neglected tropical disease category, with over 90 endemic countries, and approximately 1 million new cases and 20,000 deaths annually. Leishmania infection can progress toward the development of species–specific pathologic disorders, ranging in severity from self-healing cutaneous lesions to disseminating muco-cutaneous and fatal visceral manifestations. The severity and the outcome of leishmaniasis is determined by the parasite’s antigenic epitope characteristics, the vector physiology, and most importantly, the immune response and immune status of the host. This review examines the nature of host–pathogen interaction in leishmaniasis, innate and adaptive immune responses, and various strategies that have been employed for vaccine development. | en_US |
dc.description.sponsorship | Funding: This research received no external funding. | en_US |
dc.format.extent | 218 - 254 | - |
dc.format.medium | Electronic | - |
dc.language | en | - |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Leishmania | en_US |
dc.subject | sand fly | en_US |
dc.subject | macrophage | en_US |
dc.subject | innate immunity | en_US |
dc.subject | Th1/Th2 | en_US |
dc.subject | vaccine | en_US |
dc.title | Host–Pathogen Interaction in Leishmaniasis: Immune Response and Vaccination Strategies | en_US |
dc.title.alternative | Host-Pathogen Interaction in Leishmaniasis: Immune Response and Vaccination Strategies | - |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/immuno2010015 | - |
dc.relation.isPartOf | Immuno | - |
pubs.issue | 1 | - |
pubs.publication-status | Published online | - |
pubs.volume | 2 | - |
dc.identifier.eissn | 2673-5601 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
immuno-02-00015.pdf | 4.27 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License