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http://bura.brunel.ac.uk/handle/2438/24150Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Morse, SV | - |
| dc.contributor.author | Boltersdorf, T | - |
| dc.contributor.author | Chan, TG | - |
| dc.contributor.author | Gavins, FNE | - |
| dc.contributor.author | Choi, JJ | - |
| dc.contributor.author | Long, NJ | - |
| dc.date.accessioned | 2022-02-19T16:00:57Z | - |
| dc.date.available | 2022-02-19T16:00:57Z | - |
| dc.date.issued | 2020-09-23 | - |
| dc.identifier.citation | Morse, S.V., Boltersdorf, T., Chan, T.G., Gavins, F.N.E., Choi, J.J. and Long, N.J. (2020) 'In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia', RSC Chemical Biology, 1 (5), pp. 385 - 389. doi: 10.1039/d0cb00140f. | en_US |
| dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/24150 | - |
| dc.description.abstract | To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders. | en_US |
| dc.description.sponsorship | The PhDstudentships of S. V. M., T. B. and T. G. C. were funded by EPSRC Centre for Doctoral Training in Medical Imaging (EP/L015226/1) and the Centre for Neurotechnology (EP/L016737/1). Wethank Javier Cudeiro Blanco for his support and the Facility for Imaging by Light Microscopy (FILM) at Imperial College London funded by the Wellcome Trust (grant 104931/ZS/14/Z) and BBSRC (grant BB/L015129/1). | en_US |
| dc.format.extent | 385 - 389 | - |
| dc.format.medium | Electronic | - |
| dc.language | English | - |
| dc.language.iso | en_UK | en_UK |
| dc.publisher | Royal Society of Chemistry (RSC) | en_US |
| dc.rights | Open Access article published on 23 September 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 unported Licence (https://creativecommons.org/licenses/by-nc/3.0/). | - |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | - |
| dc.title | In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/10.1039/d0cb00140f | - |
| dc.relation.isPartOf | RSC Chemical Biology | - |
| pubs.issue | 5 | - |
| pubs.publication-status | Published online | - |
| pubs.volume | 1 | - |
| dc.identifier.eissn | 2633-0679 | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | 4.37 MB | Adobe PDF | View/Open |
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