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DC Field | Value | Language |
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dc.contributor.author | Koch Esteves, N | - |
dc.contributor.author | Gibson, OR | - |
dc.contributor.author | Khir, AW | - |
dc.contributor.author | González‐Alonso, J | - |
dc.date.accessioned | 2021-08-25T17:12:34Z | - |
dc.date.available | 2021-08-25T17:12:34Z | - |
dc.date.issued | 2021-08-04 | - |
dc.identifier | ORCID iD: Nuno Koch Esteves https://orcid.org/0000-0002-0580-7642 | - |
dc.identifier | ORCID iD: Oliver R. Gibson https://orcid.org/0000-0001-6777-5562 | - |
dc.identifier | ORCID iD: Ashraf W. Khir https://orcid.org/0000-0002-0845-2891 | - |
dc.identifier | ORCID iD: José González-Alonso https://orcid.org/0000-0002-8205-3311 | - |
dc.identifier | e14953 | - |
dc.identifier.citation | Koch Esteves, N. et al. (2021) 'Regional thermal hyperemia in the human leg: Evidence of the importance of thermosensitive mechanisms in the control of the peripheral circulation', Physiological Reports, 9 (15), e14953, pp. 1-18. doi: 10.14814/phy2.14953. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/23116 | - |
dc.description | Data availability statement: The raw, unidentified data collected throughout this study is available via Brunel Figshare, an online data repository database. https://doi.org/10.17633/rd.brunel.14749386. | - |
dc.description.abstract | Copyright © 2021 The Authors. Hyperthermia is thought to increase limb blood flow through the activation of thermosensitive mechanisms within the limb vasculature, but the precise vascular locus in which hyperthermia modulates perfusion remains elusive. We tested the hypothesis that local temperature-sensitive mechanisms alter limb hemodynamics by regulating microvascular blood flow. Temperature and oxygenation profiles and leg hemodynamics of the common (CFA), superficial (SFA) and profunda (PFA) femoral arteries, and popliteal artery (POA) of the experimental and control legs were measured in healthy participants during: (1) 3 h of whole leg heating (WLH) followed by 3 h of recovery (n = 9); (2) 1 h of upper leg heating (ULH) followed by 30 min of cooling and 1 h ULH bout (n = 8); and (3) 1 h of lower leg heating (LLH) (n = 8). WLH increased experimental leg temperature by 4.2 ± 1.2ºC and blood flow in CFA, SFA, PFA, and POA by ≥3-fold, while the core temperature essentially remained stable. Upper and lower leg blood flow increased exponentially in response to leg temperature and then declined during recovery. ULH and LLH similarly increased the corresponding segmental leg temperature, blood flow, and tissue oxygenation without affecting these responses in the non-heated leg segment, or perfusion pressure and conduit artery diameter across all vessels. Findings demonstrate that whole leg hyperthermia induces profound and sustained elevations in upper and lower limb blood flow and that segmental hyperthermia matches the regional thermal hyperemia without causing thermal or hemodynamic alterations in the non-heated limb segment. These observations support the notion that heat-activated thermosensitive mechanisms in microcirculation regulate limb tissue perfusion during hyperthermia. | en_US |
dc.description.sponsorship | This study was completed without external funding. | en_US |
dc.format.extent | 1 - 18 | - |
dc.format.medium | Electronic | - |
dc.language | English | - |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley on behalf of The Physiological Society and the American Physiological Society | en_US |
dc.rights | Copyright © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | blood flow | en_US |
dc.subject | heat | en_US |
dc.subject | hemodynamics | en_US |
dc.subject | thermal mechanisms | en_US |
dc.title | Regional thermal hyperemia in the human leg: Evidence of the importance of thermosensitive mechanisms in the control of the peripheral circulation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.14814/phy2.14953 | - |
dc.relation.isPartOf | Physiological Reports | - |
pubs.issue | 15 | - |
pubs.publication-status | Published | - |
pubs.volume | 9 | - |
dc.identifier.eissn | 2051-817X | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Dept of Life Sciences Research Papers Dept of Mechanical and Aerospace Engineering Research Papers |
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FullText.pdf | Copyright © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | 2.26 MB | Adobe PDF | View/Open |
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