Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/21627
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zahra, A | - |
dc.contributor.author | Sisu, C | - |
dc.contributor.author | Silva, E | - |
dc.contributor.author | De Aguiar Greca, S-C | - |
dc.contributor.author | Randeva, H | - |
dc.contributor.author | Chatha, K | - |
dc.contributor.author | Kyrou, I | - |
dc.contributor.author | Karteris, E | - |
dc.date.accessioned | 2020-10-08T10:44:39Z | - |
dc.date.available | 2020-10-08T10:44:39Z | - |
dc.date.issued | 2020-10-14 | - |
dc.identifier | 3296 | - |
dc.identifier.citation | Zahra, A., Sisu, C., Silva, E., De Aguiar Greca, S.-C., Randeva, H. S., Chatha, K., Kyrou, I. and Karteris, E. (2020) ‘Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?’, Journal of Clinical Medicine. MDPI AG, 9(10), 3296, pp. 1-15. doi: 10.3390/jcm9103296. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/21627 | - |
dc.description.abstract | © 2020 by the authors. Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals, so called, endocrine disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and, thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear estrogen receptors (ERα and ERβ), membrane-bound estrogen receptor GPR30 and human nuclear receptor estrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2), and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung, and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation. | en_US |
dc.description.sponsorship | Isambard Kingdom Brunel Research Scholarship | en_US |
dc.description.sponsorship | Isambard Kingdom Brunel Research Scholarship | - |
dc.format.extent | 1 - 15 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | BPA | en_US |
dc.subject | estrogen receptors | en_US |
dc.subject | ACE2 | en_US |
dc.subject | TMPRSS2 | en_US |
dc.subject | endocrine disruptors | en_US |
dc.title | Is there a link between bisphenol A (BPA), a key endocrine disruptor, and the risk for SARS-CoV-2 infection and severe COVID-19? | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/jcm9103296 | - |
dc.relation.isPartOf | Journal of Clinical Medicine | - |
pubs.issue | 10 | - |
pubs.publication-status | Published | - |
pubs.volume | 9 | - |
dc.identifier.eissn | 2077-0383 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 1.82 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License