Brunel University Research Archive(BURA) preserves and enables easy and open access to all
types of digital content. It showcases Brunel's research outputs.
Research contained within BURA is open access, although some publications may be subject
to publisher imposed embargoes. All awarded PhD theses are also archived on BURA.
Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/21134Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sales Gil, R | - |
| dc.contributor.author | Vagnarelli, P | - |
| dc.date.accessioned | 2020-07-04T12:37:07Z | - |
| dc.date.available | 2020-07-04T12:37:07Z | - |
| dc.date.issued | 2020-06-12 | - |
| dc.identifier | 1460 | - |
| dc.identifier.citation | Sales-Gil, R. and Vagnarelli, P. (2020) 'How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance', Cells, 9 (6), 1460, pp. 1-13. doi: 10.3390/cells9061460. | en_US |
| dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/21134 | - |
| dc.description.abstract | Copyright © 2020 by the authors. Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure. Besides the well-established phosphorylation of histone H3 Ser10 that has been shown to modulate HP1 binding to chromatin, several studies have recently highlighted the importance of HP1 post-translational modifications and additional epigenetic features for the modulation of HP1-chromatin binding ability and heterochromatin formation. In this review, we summarize the recent literature of HP1 post-translational modifications that have contributed to understand how heterochromatin is formed, regulated and maintained. | en_US |
| dc.description.sponsorship | Wellcome Trust Investigator award | en_US |
| dc.format.extent | 1 - 13 (13) | - |
| dc.format.medium | Electronic | - |
| dc.language | English | - |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | en_US |
| dc.rights | Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject | heterochromatin | en_US |
| dc.subject | HP1 | en_US |
| dc.subject | post-translational modifications | en_US |
| dc.subject | centromeres | en_US |
| dc.title | How HP1 post-translational modifications regulate heterochromatin formation and maintenance | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/10.3390/cells9061460 | - |
| dc.relation.isPartOf | Cells | - |
| pubs.issue | 6 | - |
| pubs.publication-status | Published | - |
| pubs.volume | 9 | - |
| dc.identifier.eissn | 2073-4409 | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | 1.1 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License
