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http://bura.brunel.ac.uk/handle/2438/21101Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lewis, A | - |
| dc.contributor.author | Russell, H | - |
| dc.contributor.author | Kedzierska, K | - |
| dc.contributor.author | Buchanan, D | - |
| dc.contributor.author | Thomas, R | - |
| dc.contributor.author | Tham, E | - |
| dc.contributor.author | Mints, M | - |
| dc.contributor.author | Keranen, A | - |
| dc.contributor.author | Giles, G | - |
| dc.contributor.author | Southey, M | - |
| dc.contributor.author | Milne, R | - |
| dc.contributor.author | Tomlinson, I | - |
| dc.contributor.author | Church, D | - |
| dc.contributor.author | Spurdle, A | - |
| dc.contributor.author | O'Mara, T | - |
| dc.date.accessioned | 2020-06-29T11:49:05Z | - |
| dc.date.available | 2020-06-29T11:49:05Z | - |
| dc.date.issued | 2020-07-08 | - |
| dc.identifier.citation | Russell, H., Kedzierska, K., Buchanan, D.D., Thomas, R., Tham, E., Mints, M., Keränen, A., Giles, G.G., Southey, M.C., Milne, R.L., Tomlinson, I., Church, D., Spurdle, A.B. O’Mara, T.A. and Lewis, A. (2020) 'The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability', Clinical Epigenetics 12, 102, pp. 1-9. https://doi.org/10.1186/s13148-020-00889-3 | en_US |
| dc.identifier.issn | 1868-7075 | - |
| dc.identifier.other | 102 | - |
| dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/21101 | - |
| dc.description.abstract | © The Author(s) 2020. Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI CRC risk, increased methylation and reduced MLH1 expression. In EC samples, we investigated rs1800734 risk using MSI and MSS cases and controls. We found no evidence that rs1800734 or other MLH1 SNPs were associated with the risk of MSI EC. We found the rs1800734 risk allele had no effect on MLH1 methylation or expression in ECs. We propose that MLH1 hypermethylation occurs by different mechanisms in CRC and EC. | - |
| dc.description.sponsorship | National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC) | - |
| dc.format.extent | 1 - 9 | - |
| dc.format.medium | Print-Electronic | - |
| dc.language.iso | en | en_US |
| dc.publisher | BMC | en_US |
| dc.rights | © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject | endometrial cancer | en_US |
| dc.subject | mismatch repair pathway | en_US |
| dc.subject | microsatellite instability | en_US |
| dc.subject | single nucleotide polymorphism | en_US |
| dc.subject | MLH1 | en_US |
| dc.subject | rs1800734 | en_US |
| dc.title | The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability | en_US |
| dc.type | Article | en_US |
| dc.relation.isPartOf | Clinical Epigenetics | - |
| pubs.publication-status | Published | - |
| pubs.volume | 12 | - |
| dc.identifier.eissn | 1868-7083 | - |
| Appears in Collections: | Dept of Life Sciences Research Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | 1.37 MB | Adobe PDF | View/Open |
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