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DC Field | Value | Language |
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dc.contributor.author | De Vries, PS | - |
dc.contributor.author | Brown, MR | - |
dc.contributor.author | Bentley, AR | - |
dc.contributor.author | Sung, YJ | - |
dc.contributor.author | Winkler, TW | - |
dc.contributor.author | Ntalla, I | - |
dc.contributor.author | Schwander, K | - |
dc.contributor.author | Kraja, AT | - |
dc.contributor.author | Guo, X | - |
dc.contributor.author | Franceschini, N | - |
dc.contributor.author | Cheng, CY | - |
dc.contributor.author | Sim, X | - |
dc.contributor.author | Vojinovic, D | - |
dc.contributor.author | Huffman, JE | - |
dc.contributor.author | Musani, SK | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Feitosa, MF | - |
dc.contributor.author | Richard, MA | - |
dc.contributor.author | Noordam, R | - |
dc.contributor.author | Aschard, H | - |
dc.contributor.author | Bartz, TM | - |
dc.contributor.author | Bielak, LF | - |
dc.contributor.author | Deng, X | - |
dc.contributor.author | Dorajoo, R | - |
dc.contributor.author | Lohman, KK | - |
dc.contributor.author | Manning, AK | - |
dc.contributor.author | Rankinen, T | - |
dc.contributor.author | Smith, AV | - |
dc.contributor.author | Tajuddin, SM | - |
dc.contributor.author | Evangelou, E | - |
dc.contributor.author | Graff, M | - |
dc.contributor.author | Alver, M | - |
dc.contributor.author | Boissel, M | - |
dc.contributor.author | Chai, JF | - |
dc.contributor.author | Chen, X | - |
dc.contributor.author | Divers, J | - |
dc.contributor.author | Gandin, I | - |
dc.contributor.author | Gao, C | - |
dc.contributor.author | Goel, A | - |
dc.contributor.author | Hagemeijer, Y | - |
dc.contributor.author | Harris, SE | - |
dc.contributor.author | Hartwig, FP | - |
dc.contributor.author | He, M | - |
dc.contributor.author | Horimoto, ARVR | - |
dc.contributor.author | Hsu, FC | - |
dc.contributor.author | Jackson, AU | - |
dc.contributor.author | Kasturiratne, A | - |
dc.contributor.author | Komulainen, P | - |
dc.contributor.author | Kühnel, B | - |
dc.contributor.author | Laguzzi, F | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Luan, J | - |
dc.contributor.author | Lyytikäinen, LP | - |
dc.contributor.author | Matoba, N | - |
dc.contributor.author | Nolte, IM | - |
dc.contributor.author | Pietzner, M | - |
dc.contributor.author | Riaz, M | - |
dc.contributor.author | Said, MA | - |
dc.contributor.author | Scott, RA | - |
dc.contributor.author | Sofer, T | - |
dc.contributor.author | Stančáková, A | - |
dc.contributor.author | Takeuchi, F | - |
dc.contributor.author | Tayo, BO | - |
dc.contributor.author | Van Der Most, PJ | - |
dc.contributor.author | Varga, TV | - |
dc.contributor.author | Wang, Y | - |
dc.contributor.author | Ware, EB | - |
dc.contributor.author | Wen, W | - |
dc.contributor.author | Yanek, LR | - |
dc.contributor.author | Zhang, W | - |
dc.contributor.author | Zhao, JH | - |
dc.contributor.author | Afaq, S | - |
dc.contributor.author | Amin, N | - |
dc.contributor.author | Amini, M | - |
dc.contributor.author | Arking, DE | - |
dc.contributor.author | Aung, T | - |
dc.contributor.author | Ballantyne, C | - |
dc.contributor.author | Boerwinkle, E | - |
dc.contributor.author | Broeckel, U | - |
dc.contributor.author | Campbell, A | - |
dc.contributor.author | Canouil, M | - |
dc.contributor.author | Charumathi, S | - |
dc.contributor.author | Chen, YDI | - |
dc.contributor.author | Connell, JM | - |
dc.contributor.author | De Faire, U | - |
dc.contributor.author | De Las Fuentes, L | - |
dc.contributor.author | De Mutsert, R | - |
dc.contributor.author | De Silva, HJ | - |
dc.contributor.author | Ding, J | - |
dc.contributor.author | Dominiczak, AF | - |
dc.contributor.author | Duan, Q | - |
dc.contributor.author | Eaton, CB | - |
dc.contributor.author | Eppinga, RN | - |
dc.contributor.author | Faul, JD | - |
dc.contributor.author | Fisher, V | - |
dc.contributor.author | Forrester, T | - |
dc.contributor.author | Franco, OH | - |
dc.contributor.author | Friedlander, Y | - |
dc.contributor.author | Ghanbari, M | - |
dc.contributor.author | Giulianini, F | - |
dc.date.accessioned | 2020-04-15T13:38:01Z | - |
dc.date.available | 2019-06-01 | - |
dc.date.available | 2020-04-15T13:38:01Z | - |
dc.date.issued | 2019-01-29 | - |
dc.identifier.citation | American Journal of Epidemiology, 2019, 188 (6), pp. 1033 - 1054 | en_US |
dc.identifier.issn | 0002-9262 | - |
dc.identifier.issn | http://dx.doi.org/10.1093/aje/kwz005 | - |
dc.identifier.issn | 1476-6256 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/20681 | - |
dc.description.abstract | © The Author(s) 2019. A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-Alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2- degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10?6) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 × 10?8 using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models. | en_US |
dc.description.sponsorship | National Heart, Lung, and Blood Institute; American Heart Association Grant | en_US |
dc.format.extent | 1033 - 1054 | - |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.subject | alcohol consumption | en_US |
dc.subject | cholesterol | en_US |
dc.subject | gene-environment interactions | en_US |
dc.subject | gene-lifestyle interactions | en_US |
dc.subject | genome-wide association studies | en_US |
dc.title | Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1093/aje/kwz005 | - |
dc.relation.isPartOf | American Journal of Epidemiology | - |
pubs.issue | 6 | - |
pubs.publication-status | Published | - |
pubs.volume | 188 | - |
dc.identifier.eissn | 1476-6256 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | 311.71 kB | Adobe PDF | View/Open |
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