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http://bura.brunel.ac.uk/handle/2438/19626
Title: | An emerging role for IQGAP1 in tight junction control |
Authors: | Tanos, BE Yeaman, C Rodriguez-Boulan, E |
Keywords: | cdc42;claudins;exocyst;IQGAP1;tight junctions |
Issue Date: | 2016 |
Publisher: | Taylor & Francis |
Citation: | Small GTPases, 2018, 9 (5), pp. 375 - 383 |
Abstract: | © 2016, © 2016 The Author(s). Published with license by Taylor & Francis. © 2016, © Barbara E. Tanos, Charles Yeaman, and Enrique Rodriguez-Boulan. IQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia. |
URI: | http://bura.brunel.ac.uk/handle/2438/19626 |
DOI: | http://dx.doi.org/10.1080/21541248.2016.1244440 |
ISSN: | 2154-1248 http://dx.doi.org/10.1080/21541248.2016.1244440 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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