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DC Field | Value | Language |
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dc.contributor.author | Sapara, A | - |
dc.contributor.author | Ffytche, DH | - |
dc.contributor.author | Cooke, MA | - |
dc.contributor.author | Williams, SCR | - |
dc.contributor.author | Kumari, V | - |
dc.date.accessioned | 2019-07-24T14:08:18Z | - |
dc.date.available | 2016-09-19 | - |
dc.date.available | 2019-07-24T14:08:18Z | - |
dc.date.issued | 2016-09-22 | - |
dc.identifier.citation | World Journal of Psychiatry, 2016, 6 (3), pp. 311 - 311 | en_US |
dc.identifier.issn | 2220-3206 | - |
dc.identifier.issn | http://dx.doi.org/10.5498/wjp.v6.i3.311 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/18855 | - |
dc.description.abstract | AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight (Insight-), relative to patients with preserved clinical insight (Insight+), and healthy controls. METHODS Forty stable schizophrenia outpatients (20 Insight- and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging (MRI). Insight in all patients was assessed using the Birchwood Insight Scale (BIS; a self-report measure). The two patient groups were pre-selected to match on most clinical and demographic parameters but, by design, they had markedly distinct BIS scores. Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain. RESULTS The three participant groups were comparable in age [F(2,57) = 0.34, P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87, P = 0.39]. Insight- and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale (PANSS): Positive symptoms [t(38) = 0.58, P = 0.57], negative symptoms [t(38) = 0.61, P = 0.55], general psychopathology [t(38) = 1.30, P = 0.20] and total PANSS scores [t(38) = 0.21, P = 0.84]. The two patient groups, as expected, varied significantly in the level of BIS-assessed insight [t(38) = 12.11, P < 0.001]. MRI results revealed lower fronto-temporal, parahippocampal, occipital and cerebellar grey matter volumes in Insight- patients, relative to Insight+ patients and healthy controls (for all clusters, family-wise error corrected P < 0.05). Insight+ patient and healthy controls did not differ significantly (P > 0.20) from each other. CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal, occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients. | en_US |
dc.format.extent | 311 - 311 | - |
dc.language.iso | en | en_US |
dc.publisher | Baishideng Publishing Group | en_US |
dc.subject | Psychosis | en_US |
dc.subject | Insight | en_US |
dc.subject | Grey matter volumes | en_US |
dc.subject | Fronto-temporal | en_US |
dc.subject | Neural networks | en_US |
dc.subject | Birchwood insight scale | en_US |
dc.title | Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.5498/wjp.v6.i3.311 | - |
dc.relation.isPartOf | World Journal of Psychiatry | - |
pubs.issue | 3 | - |
pubs.publication-status | Published | - |
pubs.volume | 6 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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FullText.pdf | 1.18 MB | Adobe PDF | View/Open |
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