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DC Field | Value | Language |
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dc.contributor.author | Somaiah, N | - |
dc.contributor.author | Chua, MLK | - |
dc.contributor.author | Bourne, S | - |
dc.contributor.author | Daley, F | - |
dc.contributor.author | A'Hern, R | - |
dc.contributor.author | Nuta, O | - |
dc.contributor.author | Gothard, L | - |
dc.contributor.author | Boyle, S | - |
dc.contributor.author | Herskind, C | - |
dc.contributor.author | Pearson, A | - |
dc.contributor.author | Warrington, J | - |
dc.contributor.author | Helyer, S | - |
dc.contributor.author | Owen, R | - |
dc.contributor.author | Rothkamm, K | - |
dc.contributor.author | Yarnold, J | - |
dc.date.accessioned | 2019-07-23T14:51:37Z | - |
dc.date.available | 2016-04-19 | - |
dc.date.available | 2019-07-23T14:51:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Radiotherapy and Oncology, 2016, 119 (2), pp. 244 - 249 | en_US |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/18845 | - |
dc.description.abstract | Aim: To correlate residual double strand breaks (DSB) 24 h after 4 Gy test doses to skin in vivo and to lymphocytes in vitro with adverse effects of earlier breast radiotherapy (RT). Patients and methods: Patients given whole breast RT P5 years earlier were identified on the basis of moderate/marked or minimal/no adverse effects despite the absence (‘RT-Sensitive’, RT-S) or presence (‘RT-Resistant’, RT-R) of variables predisposing to late adverse effects. Residual DSB were quantified in skin 24 h after a 4 Gy test dose in 20 RT-S and 15 RT-R patients. Residual DSB were quantified in lymphocytes irradiated with 4 Gy in vitro in 30/35 patients. Results: Mean foci per dermal fibroblast were 3.29 (RT-S) vs 2.80 (RT-R) (p = 0.137); 3.28 (RT-S) vs 2.60 (RT-R) in endothelium (p = 0.158); 2.50 (RT-S) vs 2.41 (RT-R) in suprabasal keratinocytes (p = 0.633); 2.70 (RT-S) vs 2.35 (RT-R) in basal epidermis (p = 0.419); 12.1 (RT-S) vs 10.3 (RT-R) in lymphocytes (p = 0.0052). Conclusions: Residual DSB in skin following a 4 Gy dose were not significantly associated with risk of late adverse effects of breast radiotherapy, although exploratory analyses suggested an association in severely affected individuals. By contrast, a significant association was detected based on the in vitro response of lymphocytes. | en_US |
dc.format.extent | 244 - 249 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Radiotherapy | en_US |
dc.subject | Late adverse effects | en_US |
dc.subject | DNA damage response | en_US |
dc.title | Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/j.radonc.2016.04.012 | - |
dc.relation.isPartOf | Radiotherapy and Oncology | - |
pubs.issue | 2 | - |
pubs.publication-status | Published | - |
pubs.volume | 119 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
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Fulltext.pdf | 909 kB | Adobe PDF | View/Open |
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