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http://bura.brunel.ac.uk/handle/2438/18598| Title: | Head Start Immunity: Characterising the early protection of C strain vaccine against subsequent classical swine fever virus infection |
| Authors: | McCarthy, RR Everett, HE Graham, SP Steinbach, F Crooke, HR |
| Keywords: | CSFV,;C strain,;ISG15,;antiviral,;vaccination;innate immunity;Classical Swine Fever |
| Issue Date: | 23-Jul-2019 |
| Publisher: | Frontiers Media |
| Citation: | McCarthy, R.R. et al. (2019) 'Head Start Immunity: Characterizing the Early Protection of C Strain Vaccine Against Subsequent Classical Swine Fever Virus Infection', Frontiers in Immunology, 10, 1584, pp. 1 - 11. doi: 10.3389/fimmu.2019.01584. |
| Abstract: | Copyright © 2019 McCarthy, Everett, Graham, Steinbach and Crooke. Classical Swine Fever Virus (CSFV) is an ongoing threat to the pig industry due to the high transmission and mortality rates associated with infection. Live attenuated vaccines such as the CSFV C strain vaccine are capable of protecting against infection within 5 days of vaccination, but the molecular mechanisms through which this early protection is mediated have yet to be established. In this study, we compared the response of pigs vaccinated with the C strain to non-vaccinated pigs both challenged with a pathogenic strain of CSFV. Analysis of transcriptomic data from the tonsils of these animals during the early stages after vaccination and challenge reveals a set of regulated genes that appear throughout the analysis. Many of these are linked to the ISG15 antiviral pathway suggesting it may play a role in the rapid and early protection conferred by C strain vaccination. |
| Description: | Supplementary Material: The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2019.01584/full#supplementary-material . |
| URI: | https://bura.brunel.ac.uk/handle/2438/18598 |
| DOI: | https://doi.org/10.3389/fimmu.2019.01584 |
| Other Identifiers: | ORCID iD: Ronan R McCarthy https://orcid.org/0000-0002-7480-6352 1584 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| FullText.pdf | Copyright © 2019 McCarthy, Everett, Graham, Steinbach and Crooke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | 3.81 MB | Adobe PDF | View/Open |
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