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http://bura.brunel.ac.uk/handle/2438/18549| Title: | GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child and adult BMI |
| Authors: | Couto Alves, A De Silva, NMG Karhunen, V Sovio, U Das, S Taal, HR Warrington, NM Lewin, AM Kaakinen, M Cousminer, DL Thiering, E Timpson, NJ Bond, TA Lowry, E Brown, CD Estivill, X Lindi, V Bradfield, JP Geller, F Speed, D Coin, LJM Loh, M Barton, SJ Beilin, LJ Bisgaard, H Bønnelykke, K Alili, R Hatoum, IJ Schramm, K Cartwright, R Charles, M Salerno, V Clément, K Claringbould, AAJ BIOS Consortium van Duijn, CM Moltchanova, E Eriksson, JG Elks, C Feenstra, B Flexeder, C Franks, S Frayling, TM Freathy, RM Elliott, P Widén, E Hakonarson, H Hattersley, AT Rodriguez, A Banterle, M Heinrich, J Heude, B Holloway, JW Hofman, A Hyppönen, E Inskip, H Kaplan, LM Hedman, AK Läärä, E Prokisch, H Grallert, H Lakka, TA Lawlor, DA Melbye, M Ahluwalia, TS Marinelli, M Millwood, IY Palmer, LJ Pennell, CE Perry, JR Ring, SM Savolainen, MJ Rivadeneira, F Standl, M Sunyer, J Tiesler, CMT Uitterlinden, AG Schierding, W O’Sullivan, JM Prokopenko, I Herzig, K Smith, GD O'Reilly, P Felix, JF Buxton, JL Blakemore, AIF Ong, KK Jaddoe, VWV Grant, SFA Sebert, S McCarthy, MI Järvelin, M. Early Growth Genetics (EGG) Consortium |
| Issue Date: | 4-Sep-2019 |
| Citation: | Couto Alves, A., De Silva, N.M.G., Karhunen, V., Sovio, U., Das, S., Taal, H.R., Warrington, N.M., Lewin, A.M., Kaakinen, M., Cousminer, D.L., Thiering, E., Timpson, N.J., Bond, T.A., Lowry, E., Brown, C.D., Estivill, X., Lindi, V., Bradfield, J.P., Geller, F., Speed, D., Coin, L.J.M., Loh, M., Barton, S.J., Beilin, L.J., Bisgaard, H., Bønnelykke, K., Alili, R., Hatoum, I.J., Schramm, K., Cartwright, R., Charles, M., Salerno, V., Clément, K., Claringbould, A.A.J., , , van Duijn, C.M., Moltchanova, E., Eriksson, J.G., Elks, C., Feenstra, B., Flexeder, C., Franks, S., Frayling, T.M., Freathy, R.M., Elliott, P., Widén, E., Hakonarson, H., Hattersley, A.T., Rodriguez, A., Banterle, M., Heinrich, J., Heude, B., Holloway, J.W., Hofman, A., Hyppönen, E., Inskip, H., Kaplan, L.M., Hedman, A.K., Läärä, E., Prokisch, H., Grallert, H., Lakka, T.A., Lawlor, D.A., Melbye, M., Ahluwalia, T.S., Marinelli, M., Millwood, I.Y., Palmer, L.J., Pennell, C.E., Perry, J.R., Ring, S.M., Savolainen, M.J., Rivadeneira, F., Standl, M., Sunyer, J., Tiesler, C.M.T., Uitterlinden, A.G., Schierding, W., O’Sullivan, J.M., Prokopenko, I., Herzig, K., Smith, G.D., O'Reilly, P., Felix, J.F., Buxton, J.L., Blakemore, A.I.F., Ong, K.K., Jaddoe, V.W.V., Grant, S.F.A., Sebert, S., McCarthy, M.I., Järvelin, M. and Early Growth Genetics (EGG) Consortium (2019) 'GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI', Science Advances, 5(9), eaaw3095, pp. 1-17. doi: 10.1126/sciadv.aaw3095. |
| Abstract: | Copyright © 2019 The Authors. Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies. |
| URI: | https://bura.brunel.ac.uk/handle/2438/18549 |
| DOI: | https://doi.org/10.1126/sciadv.aaw3095 |
| Other Identifiers: | eaaw3095 |
| Appears in Collections: | Dept of Life Sciences Research Papers |
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