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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/18197
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dc.contributor.authorAustin, CA-
dc.contributor.authorLee, KC-
dc.contributor.authorSwan, RL-
dc.contributor.authorKhazeem, MM-
dc.contributor.authorManville, CM-
dc.contributor.authorCridland, P-
dc.contributor.authorTreumann, A-
dc.contributor.authorPorter, A-
dc.contributor.authorMorris, NJ-
dc.contributor.authorCowell, IG-
dc.date.accessioned2019-05-24T12:11:59Z-
dc.date.available2019-05-24T12:11:59Z-
dc.date.issued2018-09-14-
dc.identifierORCiD: Achim Treumann https://orcid.org/0000-0002-9417-3505-
dc.identifier2765-
dc.identifier.citationAustin, C.A. et al. (2018) 'TOP2B: The first thirty years', International Journal of Molecular Sciences, 19 (9), 2765, pp. 1 - 21. doi: 10.3390/ijms19092765.en_US
dc.identifier.issn1661-6596-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/18197-
dc.description.abstractType II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery.en_US
dc.description.sponsorshipResearch in our group has been funded by a wide range of funders including Bloodwise (R.L.S., K.C.L., I.G.C., C.A.A.) formerly Leukaemia and Lymphoma Research and the Leukaemia Research Fund, Grant reference numbers, Gordon Pillar Studentship 13063 (R.L.S.); Specialist Program Grant 12031 (K.C.L., I.G.C., C.A.A.); the BBSRC (C.M., P.C.) and Newcastle University (C.A.A. & I.G.C.).-
dc.format.extent1 - 21-
dc.format.mediumPrint-Electronic-
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsCopyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjecttopoisomerase IIen_US
dc.subjectTOP2en_US
dc.subjectCell cycleen_US
dc.subjectcell biologyen_US
dc.subjecttranscriptionen_US
dc.subjectreviewen_US
dc.titleTOP2B: The first thirty yearsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/ijms19092765-
dc.relation.isPartOfInternational Journal of Molecular Sciences-
pubs.issue9-
pubs.publication-statusPublished-
pubs.volume19-
dc.identifier.eissn1422-0067-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/legalcode.en-
dc.rights.holderThe authors-
Appears in Collections:Dept of Life Sciences Research Papers

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