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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/14660
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dc.contributor.authorSpeliotes, EK-
dc.contributor.authorWiller, CJ-
dc.contributor.authorBerndt, SI-
dc.contributor.authorMonda, KL-
dc.contributor.authorThorleifsson, G-
dc.contributor.authorJackson, AU-
dc.contributor.authorAllen, HL-
dc.contributor.authorLindgren, CM-
dc.contributor.authorLuan, J-
dc.contributor.authorMaegi, R-
dc.contributor.authorRandall, JC-
dc.contributor.authorLettre, G-
dc.contributor.authorLiu, J-
dc.contributor.authorLokki, M-L-
dc.contributor.authorLorentzon, M-
dc.contributor.authorLuben, RN-
dc.contributor.authorLudwig, B-
dc.contributor.authorManunta, P-
dc.contributor.authorMarek, D-
dc.contributor.authorMarre, M-
dc.contributor.authorWheeler, E-
dc.contributor.authorBusonero, F-
dc.contributor.authorMartin, NG-
dc.contributor.authorMcArdle, WL-
dc.contributor.authorMcCarthy, A-
dc.contributor.authorMcKnight, B-
dc.contributor.authorMeitinger, T-
dc.contributor.authorMelander, O-
dc.contributor.authorMeyre, D-
dc.contributor.authorMidthjell, K-
dc.contributor.authorMontgomery, GW-
dc.contributor.authorMorken, MA-
dc.contributor.authorCampbell, H-
dc.contributor.authorWood, AR-
dc.contributor.authorMorris, AP-
dc.contributor.authorMulic, R-
dc.contributor.authorNgwa, JS-
dc.contributor.authorNelis, M-
dc.contributor.authorNeville, MJ-
dc.contributor.authorNyholt, DR-
dc.contributor.authorO'Donnell, CJ-
dc.contributor.authorO'Rahilly, S-
dc.contributor.authorOng, KK-
dc.contributor.authorCappuccio, FP-
dc.contributor.authorOostra, B-
dc.contributor.authorFerreira, T-
dc.contributor.authorPare, G-
dc.contributor.authorParker, AN-
dc.contributor.authorPerola, M-
dc.contributor.authorPichler, I-
dc.contributor.authorPietilaeinen, KH-
dc.contributor.authorPlatou, CGP-
dc.contributor.authorPolasek, O-
dc.contributor.authorPouta, A-
dc.contributor.authorCavalcanti-Proenca, C-
dc.contributor.authorRafelt, S-
dc.contributor.authorRaitakari, O-
dc.contributor.authorWeyant, RJ-
dc.contributor.authorRayner, NW-
dc.contributor.authorRidderstrale, M-
dc.contributor.authorRief, W-
dc.contributor.authorRuokonen, A-
dc.contributor.authorRobertson, NR-
dc.contributor.authorRzehak, P-
dc.contributor.authorSalomaa, V-
dc.contributor.authorChen, Y-DI-
dc.contributor.authorSanders, AR-
dc.contributor.authorSandhu, MS-
dc.contributor.authorSanna, S-
dc.contributor.authorSegre, AV-
dc.contributor.authorSaramies, J-
dc.contributor.authorSavolainen, MJ-
dc.contributor.authorScherag, S-
dc.contributor.authorSchipf, S-
dc.contributor.authorSchreiber, S-
dc.contributor.authorSchunkert, H-
dc.contributor.authorChen, C-M-
dc.contributor.authorSilander, K-
dc.contributor.authorSinisalo, J-
dc.contributor.authorSiscovick, DS-
dc.contributor.authorSmit, JH-
dc.contributor.authorEstrada, K-
dc.contributor.authorSoranzo, N-
dc.contributor.authorSovio, U-
dc.contributor.authorStephens, J-
dc.contributor.authorSurakka, I-
dc.contributor.authorSwift, AJ-
dc.contributor.authorChines, PS-
dc.contributor.authorTammesoo, M-L-
dc.contributor.authorTardif, J-C-
dc.contributor.authorTeder-Laving, M-
dc.contributor.authorTeslovich, TM-
dc.contributor.authorThompson, JR-
dc.contributor.authorLiang, L-
dc.contributor.authorThomson, B-
dc.contributor.authorToenjes, A-
dc.contributor.authorTuomi, T-
dc.contributor.authorvan Meurs, JBJ-
dc.contributor.authorClarke, R-
dc.contributor.authorvan Ommen, G-J-
dc.contributor.authorVatin, V-
dc.contributor.authorViikari, J-
dc.contributor.authorVisvikis-Siest, S-
dc.contributor.authorVitart, V-
dc.contributor.authorVogel, CIG-
dc.contributor.authorNemesh, J-
dc.contributor.authorVoight, BF-
dc.contributor.authorWaite, LL-
dc.contributor.authorWallaschofski, H-
dc.contributor.authorCoin, L-
dc.contributor.authorWalters, GB-
dc.contributor.authorWiden, E-
dc.contributor.authorWiegand, S-
dc.contributor.authorWild, SH-
dc.contributor.authorWillemsen, G-
dc.contributor.authorWitte, DR-
dc.contributor.authorWitteman, JC-
dc.contributor.authorPark, J-H-
dc.contributor.authorXu, J-
dc.contributor.authorZhang, Q-
dc.contributor.authorConnell, J-
dc.contributor.authorZgaga, L-
dc.contributor.authorZiegler, A-
dc.contributor.authorZitting, P-
dc.contributor.authorBeilby, JP-
dc.contributor.authorFarooqi, IS-
dc.contributor.authorHebebrand, J-
dc.contributor.authorHuikuri, HV-
dc.contributor.authorJames, AL-
dc.contributor.authorGustafsson, S-
dc.contributor.authorKaehoenen, M-
dc.contributor.authorVedantam, S-
dc.contributor.authorLevinson, DF-
dc.contributor.authorMacciardi, F-
dc.contributor.authorNieminen, MS-
dc.contributor.authorOhlsson, C-
dc.contributor.authorPalmer, LJ-
dc.contributor.authorRidker, PM-
dc.contributor.authorStumvoll, M-
dc.contributor.authorBeckmann, JS-
dc.contributor.authorBoeing, H-
dc.contributor.authorKilpelaenen, TO-
dc.contributor.authorDay, INM-
dc.contributor.authorBoerwinkle, E-
dc.contributor.authorBoomsma, DI-
dc.contributor.authorCaulfield, MJ-
dc.contributor.authorChanock, SJ-
dc.contributor.authorCollins, FS-
dc.contributor.authorCupples, LA-
dc.contributor.authorSmith, GD-
dc.contributor.authorErdmann, J-
dc.contributor.authorFroguel, P-
dc.contributor.authorGreonberg, H-
dc.contributor.authorden Heijer, M-
dc.contributor.authorYang, J-
dc.contributor.authorGyllensten, U-
dc.contributor.authorHall, P-
dc.contributor.authorHansen, T-
dc.contributor.authorHarris, TB-
dc.contributor.authorHattersley, AT-
dc.contributor.authorHayes, RB-
dc.contributor.authorHeinrich, J-
dc.contributor.authorHu, FB-
dc.contributor.authorHveem, K-
dc.contributor.authorDuan, J-
dc.contributor.authorIllig, T-
dc.contributor.authorBouatia-Naji, N-
dc.contributor.authorJarvelin, M-R-
dc.contributor.authorKaprio, J-
dc.contributor.authorKarpe, F-
dc.contributor.authorKhaw, K-T-
dc.contributor.authorKiemeney, LA-
dc.contributor.authorKrude, H-
dc.contributor.authorLaakso, M-
dc.contributor.authorLawlor, DA-
dc.contributor.authorEbrahim, S-
dc.contributor.authorMetspalu, A-
dc.contributor.authorMunroe, PB-
dc.contributor.authorEsko, T-
dc.contributor.authorOuwehand, WH-
dc.contributor.authorPedersen, O-
dc.contributor.authorPenninx, BW-
dc.contributor.authorPeters, A-
dc.contributor.authorPramstaller, PP-
dc.contributor.authorQuertermous, T-
dc.contributor.authorReinehr, T-
dc.contributor.authorElliott, P-
dc.contributor.authorRissanen, A-
dc.contributor.authorRudan, I-
dc.contributor.authorSamani, NJ-
dc.contributor.authorFeitosa, MF-
dc.contributor.authorSchwarz, PEH-
dc.contributor.authorShuldiner, AR-
dc.contributor.authorSpector, TD-
dc.contributor.authorTuomilehto, J-
dc.contributor.authorUda, M-
dc.contributor.authorUitterlinden, A-
dc.contributor.authorElosua, R-
dc.contributor.authorValle, TT-
dc.contributor.authorWabitsch, M-
dc.contributor.authorWaeber, G-
dc.contributor.authorWareham, NJ-
dc.contributor.authorKutalik, Z-
dc.contributor.authorWatkins, H-
dc.contributor.authorWilson, JF-
dc.contributor.authorWright, AF-
dc.contributor.authorZillikens, MC-
dc.contributor.authorChatterjee, N-
dc.contributor.authorEiriksdottir, G-
dc.contributor.authorMcCarroll, SA-
dc.contributor.authorPurcell, S-
dc.contributor.authorSchadt, EE-
dc.contributor.authorVisscher, PM-
dc.contributor.authorAssimes, TL-
dc.contributor.authorMangino, M-
dc.contributor.authorBorecki, IB-
dc.contributor.authorDeloukas, P-
dc.contributor.authorFox, CS-
dc.contributor.authorGroop, LC-
dc.contributor.authorErdos, MR-
dc.contributor.authorHaritunians, T-
dc.contributor.authorHunter, DJ-
dc.contributor.authorKaplan, RC-
dc.contributor.authorMohlke, KL-
dc.contributor.authorO'Connell, JR-
dc.contributor.authorPeltonen, L-
dc.contributor.authorRaychaudhuri, S-
dc.contributor.authorSchlessinger, D-
dc.contributor.authorStrachan, DP-
dc.contributor.authorvan Duijn, CM-
dc.contributor.authorEriksson, JG-
dc.contributor.authorWichmann, H-E-
dc.contributor.authorFrayling, TM-
dc.contributor.authorThorsteinsdottir, U-
dc.contributor.authorAbecasis, GR-
dc.contributor.authorBarroso, I-
dc.contributor.authorBoehnke, M-
dc.contributor.authorStefansson, K-
dc.contributor.authorScherag, A-
dc.contributor.authorNorth, KE-
dc.contributor.authorMcCarthy, MI-
dc.contributor.authorFacheris, MF-
dc.contributor.authorHirschhorn, JN-
dc.contributor.authorIngelsson, E-
dc.contributor.authorLoos, RJF-
dc.contributor.authorSmith, AV-
dc.contributor.authorWelch, R-
dc.contributor.authorZhao, JH-
dc.contributor.authorAben, KK-
dc.contributor.authorAbsher, DM-
dc.contributor.authorAmin, N-
dc.contributor.authorDixon, AL-
dc.contributor.authorWinkler, TW-
dc.contributor.authorFisher, E-
dc.contributor.authorGlazer, NL-
dc.contributor.authorGoddard, ME-
dc.contributor.authorHeard-Costa, NL-
dc.contributor.authorHoesel, V-
dc.contributor.authorHottenga, J-J-
dc.contributor.authorJohansson, A-
dc.contributor.authorJohnson, T-
dc.contributor.authorKetkar, S-
dc.contributor.authorLamina, C-
dc.contributor.authorFelix, SB-
dc.contributor.authorLi, S-
dc.contributor.authorMoffatt, MF-
dc.contributor.authorMyers, RH-
dc.contributor.authorNarisu, N-
dc.contributor.authorPerry, JRB-
dc.contributor.authorPeters, MJ-
dc.contributor.authorPreuss, M-
dc.contributor.authorRipatti, S-
dc.contributor.authorRivadeneira, F-
dc.contributor.authorSandholt, C-
dc.contributor.authorFischer-Posovszky, P-
dc.contributor.authorScott, LJ-
dc.contributor.authorTimpson, NJ-
dc.contributor.authorTyrer, JP-
dc.contributor.authorvan Wingerden, S-
dc.contributor.authorWatanabe, RM-
dc.contributor.authorWhite, CC-
dc.contributor.authorWiklund, F-
dc.contributor.authorBarlassina, C-
dc.contributor.authorChasman, DI-
dc.contributor.authorCooper, MN-
dc.contributor.authorFolsom, AR-
dc.contributor.authorJansson, J-O-
dc.contributor.authorLawrence, RW-
dc.contributor.authorPellikka, N-
dc.contributor.authorProkopenko, I-
dc.contributor.authorShi, J-
dc.contributor.authorThiering, E-
dc.contributor.authorAlavere, H-
dc.contributor.authorAlibrandi, MTS-
dc.contributor.authorAlmgren, P-
dc.contributor.authorArnold, AM-
dc.contributor.authorFriedrich, N-
dc.contributor.authorAspelund, T-
dc.contributor.authorAtwood, LD-
dc.contributor.authorBalkau, B-
dc.contributor.authorBalmforth, AJ-
dc.contributor.authorBennett, AJ-
dc.contributor.authorBen-Shlomo, Y-
dc.contributor.authorBergman, RN-
dc.contributor.authorBergmann, S-
dc.contributor.authorBiebermann, H-
dc.contributor.authorBlakemore, AIF-
dc.contributor.authorFreimer, NB-
dc.contributor.authorBoes, T-
dc.contributor.authorBonnycastle, LL-
dc.contributor.authorBornstein, SR-
dc.contributor.authorBrown, MJ-
dc.contributor.authorBuchanan, TA-
dc.contributor.authorFu, M-
dc.contributor.authorGaget, S-
dc.contributor.authorGejman, PV-
dc.contributor.authorGeus, EJC-
dc.contributor.authorGieger, C-
dc.contributor.authorQi, L-
dc.contributor.authorGjesing, AP-
dc.contributor.authorGoel, A-
dc.contributor.authorGoyette, P-
dc.contributor.authorGrallert, H-
dc.contributor.authorGraessler, J-
dc.contributor.authorGreenawalt, DM-
dc.contributor.authorGroves, CJ-
dc.contributor.authorGudnason, V-
dc.contributor.authorGuiducci, C-
dc.contributor.authorHartikainen, A-L-
dc.contributor.authorWorkalemahu, T-
dc.contributor.authorHassanali, N-
dc.contributor.authorHall, AS-
dc.contributor.authorHavulinna, AS-
dc.contributor.authorHayward, C-
dc.contributor.authorHeath, AC-
dc.contributor.authorHengstenberg, C-
dc.contributor.authorHicks, AA-
dc.contributor.authorHinney, A-
dc.contributor.authorHofman, A-
dc.contributor.authorHomuth, G-
dc.contributor.authorHeid, IM-
dc.contributor.authorHui, J-
dc.contributor.authorIgl, W-
dc.contributor.authorIribarren, C-
dc.contributor.authorIsomaa, B-
dc.contributor.authorJacobs, KB-
dc.contributor.authorJarick, I-
dc.contributor.authorJewell, E-
dc.contributor.authorJohn, U-
dc.contributor.authorJorgensen, T-
dc.contributor.authorJousilahti, P-
dc.contributor.authorSteinthorsdottir, V-
dc.contributor.authorJula, A-
dc.contributor.authorKaakinen, M-
dc.contributor.authorKajantie, E-
dc.contributor.authorKaplan, LM-
dc.contributor.authorKathiresan, S-
dc.contributor.authorKettunen, J-
dc.contributor.authorKinnunen, L-
dc.contributor.authorKnowles, JW-
dc.contributor.authorKolcic, I-
dc.contributor.authorKoenig, IR-
dc.contributor.authorStringham, HM-
dc.contributor.authorKoskinen, S-
dc.contributor.authorKovacs, P-
dc.contributor.authorKuusisto, J-
dc.contributor.authorKraft, P-
dc.contributor.authorKvaloy, K-
dc.contributor.authorLaitinen, J-
dc.contributor.authorLantieri, O-
dc.contributor.authorLanzani, C-
dc.contributor.authorLauner, LJ-
dc.contributor.authorLecoeur, C-
dc.contributor.authorWeedon, MN-
dc.contributor.authorLehtimaeki, T-
dc.date.accessioned2017-06-01T13:48:38Z-
dc.date.available2010-11-01-
dc.date.available2017-06-01T13:48:38Z-
dc.date.issued2010-
dc.identifier.citationNATURE GENETICS, 42 (11): pp. 937 - U53 (14), (2010)en_US
dc.identifier.issnhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283540500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5-
dc.identifier.issnhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283540500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5-
dc.identifier.issn1061-4036-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/14660-
dc.description.abstractObesity is globally prevalent and highly heritable, but the underlying genetic factors remain largely elusive. To identify genetic loci for obesity-susceptibility, we examined associations between body mass index (BMI) and ~2.8 million SNPs in up to 123,865 individuals, with targeted follow-up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity-susceptibility loci and identified 18 new loci associated with BMI (P<5×10−8), one of which includes a copy number variant near GPRC5B. Some loci (MC4R, POMC, SH2B1, BDNF) map near key hypothalamic regulators of energy balance, and one is near GIPR, an incretin receptor. Furthermore, genes in other newly-associated loci may provide novel insights into human body weight regulation.en_US
dc.format.extent937 - U53 (14)-
dc.languageEnglish-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectScience & Technologyen_US
dc.subjectLife Sciences & Biomedicineen_US
dc.subjectGenetics & Heredityen_US
dc.subjectGENETICS & HEREDITYen_US
dc.subjectGENOME-WIDE ASSOCIATIONen_US
dc.subjectGASTRIC-INHIBITORY POLYPEPTIDEen_US
dc.subjectMELANOCORTIN-4 RECEPTOR GENEen_US
dc.subjectGLUCOSE-HOMEOSTASISen_US
dc.subjectCOMMON VARIANTSen_US
dc.subjectADULT OBESITYen_US
dc.subjectEARLY-ONSETen_US
dc.subjectFTO GENEen_US
dc.subjectFAT MASSen_US
dc.subjectRISKen_US
dc.titleAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass indexen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1038/ng.686-
dc.relation.isPartOfNATURE GENETICS-
pubs.issue11-
pubs.publication-statusPublished-
pubs.volume42-
Appears in Collections:Dept of Life Sciences Research Papers

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