Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/14647
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dorajoo, R | - |
dc.contributor.author | Li, R | - |
dc.contributor.author | Ikram, MK | - |
dc.contributor.author | Liu, J | - |
dc.contributor.author | Froguel, P | - |
dc.contributor.author | Lee, J | - |
dc.contributor.author | Sim, X | - |
dc.contributor.author | Ong, RT-H | - |
dc.contributor.author | Tay, WT | - |
dc.contributor.author | Peng, C | - |
dc.contributor.author | Young, TL | - |
dc.contributor.author | Blakemore, AIF | - |
dc.contributor.author | Cheng, CY | - |
dc.contributor.author | Aung, T | - |
dc.contributor.author | Mitchell, P | - |
dc.contributor.author | Wang, JJ | - |
dc.contributor.author | Klaver, CC | - |
dc.contributor.author | Boerwinkle, E | - |
dc.contributor.author | Klein, R | - |
dc.contributor.author | Siscovick, DS | - |
dc.contributor.author | Jensen, RA | - |
dc.contributor.author | Gudnason, V | - |
dc.contributor.author | Smith, AV | - |
dc.contributor.author | Teo, YY | - |
dc.contributor.author | Wong, TY | - |
dc.contributor.author | Tai, E-S | - |
dc.contributor.author | Heng, C-K | - |
dc.contributor.author | Friedlander, Y | - |
dc.date.accessioned | 2017-06-01T10:27:18Z | - |
dc.date.available | 2013-07-02 | - |
dc.date.available | 2017-06-01T10:27:18Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | PLOS ONE, 8 (7):(2013) | en_US |
dc.identifier.issn | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321341000066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 | - |
dc.identifier.issn | ARTN e67650 | - |
dc.identifier.issn | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000321341000066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 | - |
dc.identifier.issn | ARTN e67650 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/14647 | - |
dc.description.abstract | Introduction: C-reactive protein (CRP) levels are associated with cardiovascular disease and systemic inflammation. We assessed whether CRP-associated loci were associated with serum CRP and retinal markers of microvascular disease, in Asian populations. Methods: Genome-wide association analysis (GWAS) for serum CRP was performed in East-Asian Chinese (N = 2,434) and Malays (N = 2,542) and South-Asian Indians (N = 2,538) from Singapore. Leveraging on GWAS data, we assessed, in silico, association levels among the Singaporean datasets for 22 recently identified CRP-associated loci. At loci where directional inconsistencies were observed, quantification of inter-ethnic linkage disequilibrium (LD) difference was determined. Next, we assessed association for a variant at CRP and retinal vessel traits [central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE)] in a total of 24,132 subjects of East-Asian, South-Asian and European ancestry. Results: Serum CRP was associated with SNPs in/near APOE, CRP, HNF1A and LEPR (p-values #4.761028) after meta-analysis of Singaporean populations. Using a candidate-SNP approach, we further replicated SNPs at 4 additional loci that had been recently identified to be associated with serum CRP (IL6R, GCKR, IL6 and IL1F10) (p-values #0.009), in the Singaporean datasets. SNPs from these 8 loci explained 4.05% of variance in serum CRP. Two SNPs (rs2847281 and rs6901250) were detected to be significant (p-value #0.036) but with opposite effect directions in the Singaporean populations as compared to original European studies. At these loci we did not detect significant inter-population LD differences. We further did not observe a significant association between CRP variant and CRVE or CRAE levels after meta-analysis of all Singaporean and European datasets (p-value .0.058). Conclusions: Common variants associated with serum CRP, first detected in primarily European studies, are also associated with CRP levels in East-Asian and South-Asian populations. We did not find a causal link between CRP and retinal measures of microvascular disease. | en_US |
dc.format.extent | ? - ? (9) | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.subject | Science & Technology | en_US |
dc.subject | Multidisciplinary Sciences | en_US |
dc.subject | Science & Technology - Other Topics | en_US |
dc.subject | MULTIDISCIPLINARY SCIENCES | en_US |
dc.subject | CORONARY-HEART-DISEASE | en_US |
dc.subject | GENOME-WIDE ASSOCIATION | en_US |
dc.subject | CHRONIC KIDNEY-DISEASE | en_US |
dc.subject | CARDIOVASCULAR RISK-FACTORS | en_US |
dc.subject | ATHEROSCLEROSIS RISK | en_US |
dc.subject | METABOLIC-SYNDROME | en_US |
dc.subject | VESSEL CALIBER | en_US |
dc.subject | INFLAMMATION | en_US |
dc.subject | HEALTH | en_US |
dc.subject | LOCI | en_US |
dc.title | Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0067650 | - |
dc.relation.isPartOf | PLOS ONE | - |
pubs.issue | 7 | - |
pubs.publication-status | Published | - |
pubs.volume | 8 | - |
Appears in Collections: | Dept of Life Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 1.17 MB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.