Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/5542
Title: | Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay |
Authors: | Miller, D Wheals, BB Beresford, NA Sumpter, JP |
Keywords: | Estrogenic activity;Phenolic additives;Recombinant yeast assay |
Issue Date: | 2001 |
Publisher: | National Institute of Environmental Health Sciences (NIEHS) |
Citation: | Environmental Health Perspectives 109(2): 133 - 138, Feb 2001 |
Abstract: | We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17 beta -estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17<beta>-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da. |
Description: | Copyright @ 2001 Environmental Health Perspectives |
URI: | http://bura.brunel.ac.uk/handle/2438/5542 |
DOI: | http://dx.doi.org/10.1289/ehp.01109133 |
ISSN: | 0091-6765 |
Appears in Collections: | Publications |
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