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http://bura.brunel.ac.uk/handle/2438/3057
Title: | Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals |
Authors: | Jobling, S Sheahan, D Osborne, JA Matthiessen, P Sumpter, JP |
Keywords: | Rainbow trout, Oncorhynchus mykiss, Alkylphenol, Testicular growth, Estrogen |
Issue Date: | 1996 |
Publisher: | Society of Environmental Toxicology and Chemistry Press |
Citation: | Environmental Toxicology and Chemistry. 15 (2) 194–202 |
Abstract: | It is becoming evident that an increasing number of widely used industrial and agricultural chemicals are estrogenic. The biodegradation products of a major group of nonionic surfactants, the alkylphenol polyethoxylates, are one such group. Some of these chemicals are widespread aquatic pollutants, and bioconcentrate in aquatic biota. Exposure of male rainbow trout (Oncorhynchus mykiss) to four different alkylphenolic chemicals caused synthesis of vitellogenin, a process normally dependent on endogenous estrogens, and a concomitant inhibition of testicular growth. The magnitude of these estrogenic effects was dependent on the estrogenic potency of the chemical, the stage of reproductive development of the fish, and the concentration of the chemical in the water. These results support the contention that exposure of wildlife to environmentally persistent estrogenic chemicals can result in deleterious reproductive consequences. |
URI: | http://bura.brunel.ac.uk/handle/2438/3057 |
ISSN: | 0730-7268 |
Appears in Collections: | Environment Institute for the Environment |
Files in This Item:
File | Description | Size | Format | |
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Closed Access Paper.txt | 278 B | Text | View/Open |
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