Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/29759
Title: Therapeutic Effect of Superficial Scalp Hypothermia on Chemotherapy-Induced Alopecia in Breast Cancer Survivors
Authors: Mokbel, K
Kodresko, A
Trembley, J
Jouhara, H
Keywords: alopecia;breast cancer;chemotherapy-induced alopecia;cryotherapy;hair loss;scalp hypothermia;scalp cooling
Issue Date: 12-Sep-2024
Publisher: MDPI
Citation: Mokbel K. et al. (2024) 'Therapeutic Effect of Superficial Scalp Hypothermia on Chemotherapy-Induced Alopecia in Breast Cancer Survivors', Journal of Clinical Medicine, 13 (18), 5397, pp. 1 - 17. doi: 10.3390/jcm13185397.
Abstract: Alopecia is a common adverse effect of neoadjuvant or adjuvant chemotherapy in patients with early breast cancer. While hair typically regrows over time, more than 40% of patients continue to suffer from permanent partial alopecia, significantly affecting body image, psychological well-being, and quality of life. This concern is a recognized reason why some breast cancer patients decline life-saving chemotherapy. It is critical for healthcare professionals to consider the impact of this distressing side effect and adopt supportive measures to mitigate it. Among the various strategies investigated to reduce chemotherapy-induced alopecia (CIA), scalp cooling has emerged as the most effective. This article reviews the pathophysiology of CIA and examines the efficacy of different scalp cooling methods. Scalp cooling has been shown to reduce the incidence of CIA, defined as less than 50% hair loss, by 50% in patients receiving chemotherapy. It is associated with high patient satisfaction and does not significantly increase the risk of scalp metastasis or compromise overall survival. Promising new scalp cooling technologies, such as cryogenic nitrogen oxide cryotherapy, offer the potential to achieve and maintain lower scalp temperatures, potentially enhancing therapeutic effects. Further investigation into these approaches is warranted. Research on CIA is hindered by significant heterogeneity and the lack of standardised methods for assessing hair loss. To advance the field, further interdisciplinary research is crucial to develop preclinical models of CIA, establish a uniform, internationally accepted and standardised classification system, and establish an objective, personalised prognosis monitoring system.
URI: https://bura.brunel.ac.uk/handle/2438/29759
DOI: https://doi.org/10.3390/jcm13185397
Other Identifiers: ORCiD: Kefah Mokbel https://orcid.org/0000-0001-7255-7850
ORCiD: Alevtina Kodresko https://orcid.org/0009-0004-3434-3543
ORCiD: Hussam Jouhara https://orcid.org/0000-0002-6910-6116
5397
Appears in Collections:Dept of Mechanical and Aerospace Engineering Research Papers

Files in This Item:
File Description SizeFormat 
FullText.pdfCopyright © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).6.64 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons