Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/23757
Title: Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods
Authors: Nilsson, C
Issue Date: 19-Apr-2020
Publisher: Nordisk Ministerråd
Citation: Nilsson, C. (2020) Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods. Copenhagen: Nordisk Ministerråd, pp. 1 - 116 (116) (TemaNord 2020:507). doi: 10.6027/temanord2020-507.
Series/Report no.: TemaNord;2020:507
Abstract: This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.
Description: The draft-DRP [OECD Detailed Review Paper (DRP) 178 on endocrine disrupter testing] was authored by Alice Baynes and Edwin Routledge, Brunel University, London, and Sofie Christiansen and Ulla Hass, Technical University of Denmark. Parts of the draft-DRP have, with the permission of the European Commission, been incorporated in this report. The main author of this TemaNord report is Dr. Charlotte Nilsson, RISE Research Institutes of Sweden. Dr. Miriam Jacobs (Public Health England) is the main author of the sections Heterodimerisation partners and cross-talk and Epigenetics and its role in the retinoid system. The in-kind contributions from scientific experts involved in writing and reviewing this document is gratefully acknowledged (see list of contributors). This report is publicly available via the NKE website4, and describes the status as of December 2019.
URI: https://bura.brunel.ac.uk/handle/2438/23757
DOI: https://doi.org/10.6027/temanord2020-507
ISBN: 978-92-893-6530-7
978-92-893-6531-4
ISSN: 0908-6692
Other Identifiers: 2020:507
Appears in Collections:Dept of Life Sciences Research Papers

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