Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/15971
Title: Adverse outcome pathway networks I: Development and applications
Authors: Knapen, D
Angrish, MM
Fortin, MC
Katsiadaki, I
Leonard, M
Margiotta-Casaluci, L
Munn, S
O'Brien, JM
Pollesch, N
Smith, LC
Zhang, X
Villeneuve, DL
Keywords: AOP network;Adverse outcome pathway;network development;network topology;predictive toxicology;risk assessment
Issue Date: 28-Feb-2018
Publisher: Wiley on behalf of Society of Environmental Toxicology and Chemistry (SETAC)
Citation: Knapen, D. et al. (2018) 'Adverse outcome pathway networks I: Development and applications', Environmental Toxicology and Chemistry, 37 (6), pp. 1723 - 1733. doi: 10.1002/etc.4125.
Abstract: Copyright © 2018 The Authors. Based on the results of a SETAC-sponsored Horizon Scanning exercise focused on advancing the adverse outcome pathway (AOP) framework, the development of guidance related to AOP network development was identified as a critical need. This not only included questions focusing directly on AOP networks, but also on related topics such as mixture toxicity assessment and the implementation of feedback loops within the AOP framework. A set of two papers has been developed to begin exploring these concepts. In the present paper (part I), derivation of AOP networks is considered in the context of how it differs from development of individual AOPs. We then propose the use of filters and layers to tailor AOP networks to suit the needs of a given research question or application. We briefly introduce a number of analytical approaches that may be used to characterize the structure of AOP networks. These analytical concepts are further described in a dedicated, complementary paper (part II). Finally, we present a number of case studies that illustrate concepts underlying development, analysis and application of AOP networks. The concepts described in this paper, and in its companion paper focused on AOP network analytics, are intended to serve as a starting point for further development of the AOP network concept, but also to catalyze AOP network development and application by the different stakeholder communities. This article is protected by copyright. All rights reserved.
Description: Data Availability: Data, associated metadata, and calculation tools are available from the corresponding author (dries.knapen@uantwerpen.be).
Supplemental Data: The Supplemental Data are available on the Wiley Online Library at DOI: https://doi.org/10.1002/etc.4125.
URI: https://bura.brunel.ac.uk/handle/2438/15971
DOI: https://doi.org/10.1002/etc.4125
ISSN: 1552-8618
Appears in Collections:Dept of Life Sciences Research Papers

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