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DC Field | Value | Language |
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dc.contributor.author | Harris, CA | - |
dc.contributor.author | Scholze, M | - |
dc.contributor.author | Backhaus, T | - |
dc.contributor.author | Booy, P | - |
dc.contributor.author | Lamoree, M | - |
dc.contributor.author | Pojana, G | - |
dc.contributor.author | Jonkers, N | - |
dc.contributor.author | Runnalls, T | - |
dc.contributor.author | Bonfa, A | - |
dc.contributor.author | Marcomini, A | - |
dc.contributor.author | Sumpter, JP | - |
dc.coverage.spatial | 8 | en |
dc.date.accessioned | 2007-09-05T11:04:17Z | - |
dc.date.accessioned | 2014-03-24T16:13:50Z | - |
dc.date.available | 2014-03-24T16:13:50Z | - |
dc.date.issued | 2005-03-14 | - |
dc.identifier.citation | Harris, C.A. et al. (2005) 'Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals', Environmental Health Perspectives, 113 (6), pp. 721 - 728. doi: 10.1289/ehp.7598. | en_US |
dc.identifier.issn | 0091-6765 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/8178 | - |
dc.description | Reproduced with permission from Environmental Health Perspectives. | en_US |
dc.description.abstract | Existing environmental risk assessment procedures are limited in their ability to evaluate the combined effects of chemical mixtures. We investigated the implications of this by analyzing the combined effects of a multicomponent mixture of five estrogenic chemicals using vitellogenin induction in male fathead minnows as an end point. The mixture consisted of estradiol, ethynylestradiol, nonylphenol, octylphenol, and bisphenol A. We determined concentration–response curves for each of the chemicals individually. The chemicals were then combined at equipotent concentrations and the mixture tested using fixed-ratio design. The effects of the mixture were compared with those predicted by the model of concentration addition using biomathematical methods, which revealed that there was no deviation between the observed and predicted effects of the mixture. These findings demonstrate that estrogenic chemicals have the capacity to act together in an additive manner and that their combined effects can be accurately predicted by concentration addition. We also explored the potential for mixture effects at low concentrations by exposing the fish to each chemical at one-fifth of its median effective concentration (EC50). Individually, the chemicals did not induce a significant response, although their combined effects were consistent with the predictions of concentration addition. This demonstrates the potential for estrogenic chemicals to act additively at environmentally relevant concentrations. These findings highlight the potential for existing environmental risk assessment procedures to underestimate the hazard posed by mixtures of chemicals that act via a similar mode of action, thereby leading to erroneous conclusions of absence of risk. | en_US |
dc.description.sponsorship | European Commission under the 5th Framework Programme (contract EVK1-2001-00091). | en_US |
dc.format.extent | 619146 bytes | - |
dc.format.extent | 721 - 728 | - |
dc.format.medium | Print-Electronic | - |
dc.format.mimetype | application/pdf | - |
dc.language | English | - |
dc.language.iso | en | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.ispartof | 113; | - |
dc.relation.replaces | https://bura.brunel.ac.uk/handle/2438/1199 | - |
dc.relation.replaces | 2438/1199 | - |
dc.rights | Copyright © The Authors 2005. Published by and Reproduced with permission from Environmental Health Perspectives. LICENSE INFORMATION: EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. | - |
dc.subject | concentration addition | en_US |
dc.subject | estrogen | en_US |
dc.subject | estrogen mimic | en_US |
dc.subject | fathead minnow | en_US |
dc.subject | mixture effects | en_US |
dc.subject | Pimephales promelas | en_US |
dc.subject | Prediction | en_US |
dc.title | Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1289/ehp.7598 | - |
pubs.issue | 6 | - |
pubs.volume | 113 | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Active Staff | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/Institute for the Environment | - |
pubs.organisational-data | /Brunel/Brunel Active Staff/Institute for the Environment/Institute for the Environment | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups | - |
pubs.organisational-data | /Brunel/University Research Centres and Groups/School of Health Sciences and Social Care - URCs and Groups/Centre for Systems and Synthetic Biology | - |
dc.identifier.eissn | 1552-9924 | - |
dc.rights.holder | The Authors | - |
Appears in Collections: | Environment Institute for the Environment |
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File | Description | Size | Format | |
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Fulltext.pdf | Copyright © The Authors 2005. Published by and Reproduced with permission from Environmental Health Perspectives. LICENSE INFORMATION: EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. | 604.63 kB | Adobe PDF | View/Open |
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