Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/3065
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Argaman, M | - |
dc.contributor.author | Gidron, Y | - |
dc.contributor.author | Ariad, S | - |
dc.coverage.spatial | 11 | en |
dc.date.accessioned | 2009-02-26T13:06:04Z | - |
dc.date.available | 2009-02-26T13:06:04Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | International Journal of Behavioral Medicine. 12(3): 16 -170 | en |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/3065 | - |
dc.description.abstract | A model of the relations between psychological factors and cancer progression should include brain and systemic components and their link with critical cellular stages in cancer progression. We present a psychoneuroimmunological (PNI) model that links helplessness-hopelessness (HH) with cancer progression via interleukin-1β (IL-1β). IL-1β was elevated in the brain following exposure to inescapable shock, and HH was minimized by antagonizing cerebral IL-1β. Elevated cerebral IL-1β increased cancer metastasis in animals. Inescapable shock was associated with systemic elevations of IL-1β and peripheral IL-1β was associated with escape from apoptosis, angiogenesis, and metastasis. Involvement of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are discussed. Future studies need to identify the role of additional factors in this PNI pathway. | en |
dc.format.extent | 275591 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | Lawrence Erlbaum Associates | en |
dc.subject | Hopelessness; Cancer; Progression; Psychoneuroimmunology; IL-1β | en |
dc.title | Interleukin-1 may link helplessness-hopelessness with cancer progression: A proposed model | en |
dc.type | Research Paper | en |
dc.identifier.doi | http://dx.doi.org/10.1207/s15327558ijbm1203_5 | - |
Appears in Collections: | Community Health and Public Health Dept of Health Sciences Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
803101_751310820_784771017.pdf | 269.13 kB | Adobe PDF | View/Open |
Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.