Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent (ATPS) systems: Its scale-up and prospects for the future production of high-value biologics

Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/2800

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DC Field	Value	Language
dc.contributor.author	Sutherland, I A	-
dc.coverage.spatial	21	en
dc.date.accessioned	2008-11-04T11:42:42Z	-
dc.date.available	2008-11-04T11:42:42Z	-
dc.date.issued	2007	-
dc.identifier.citation	Current Opinion in Drug Discovery & Development. 10 (6) 540-549	en
dc.identifier.uri	http://bura.brunel.ac.uk/handle/2438/2800	-
dc.description.abstract	The future challenges in bioprocessing include developing new downstream processes for the purification and manufacture of the protein based medicines of the future to relieve the predicted bottleneck being produced by increasingly high titres from fermentation processes. This review looks at the recent developments in centrifugal liquid-liquid partition chromatography using aqueous two-phase solvent (ATPS) systems, a gentle host medium for biologics, and the prospect for scale-up and eventual manufacture of high value pharmaceutical products.	en
dc.format.extent	1806336 bytes	-
dc.format.mimetype	application/msword	-
dc.language.iso	en	-
dc.publisher	BioMed Central	en
dc.subject	Aqueous two-phase solvents, ATPS, aqueous-aqueous polymer phase systems, centrifugal partition chromatography, CPC, Countercurrent chromatography, CCC, HSCCC	en
dc.title	Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent (ATPS) systems: Its scale-up and prospects for the future production of high-value biologics	en
dc.type	Research Paper	en
Appears in Collections:	Brunel Institute for Bioengineering (BIB) Biological Sciences

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