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DC Field | Value | Language |
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dc.contributor.author | Ramzi, NH | - |
dc.contributor.author | Auvinen, J | - |
dc.contributor.author | Veijola, J | - |
dc.contributor.author | Miettunen, J | - |
dc.contributor.author | Ala-Mursula, L | - |
dc.contributor.author | Sebert, S | - |
dc.contributor.author | Keinänen-Kiukaanniemi, S | - |
dc.contributor.author | Svento, R | - |
dc.contributor.author | Jokelainen, J | - |
dc.contributor.author | Drenos, F | - |
dc.contributor.author | Dovey, TM | - |
dc.contributor.author | Järvelin, M-R | - |
dc.contributor.author | Blakemore, AIF | - |
dc.date.accessioned | 2023-05-11T07:21:27Z | - |
dc.date.available | 2023-05-11T07:21:27Z | - |
dc.date.issued | 2023-03-16 | - |
dc.identifier | ORCID iDs: Fotios Drenos https://orcid.org/0000-0003-2469-5516; Terence M. Dovey Terence M. Dovey; Alexandra I.F. Blakemore https://orcid.org/0000-0003-0661-564X. | - |
dc.identifier.citation | Ramzi, N.H. et al. (2023) 'Depression mediates the relationship between alexithymia and obesity in the Northern Finland Birth Cohort 1966 (NFBC1966)', Journal of Affective Disorders, 331, pp. 1 - 7. doi: 10.1016/j.jad.2023.03.026. | en_US |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/26439 | - |
dc.description | Data availability: NFBC data is available from the University of Oulu, Infrastructure for Population Studies. Permission to use the data can be applied for research purposes via electronic material request portal. In the use of data, we follow the EU general data protection regulation (679/2016) and Finnish Data Protection Act. The use of personal data is based on cohort participant's written informed consent at his/her latest follow-up study, which may cause limitations to its use. Please contact NFBC project center (NFBCprojectcenter@oulu.fi) and visit the cohort website for more information. | en_US |
dc.description.abstract | Background: The fact that a complex relationship exists between alexithymia and body mass index (BMI) is well established, but the underlying mechanisms remain poorly understood. Here, we explore the relationship between alexithymia and depressive symptoms in relation to adiposity measures, including the direct and indirect effect of alexithymia and depressive symptoms on obesity over a 15-year time-period, in the Northern Finland Birth Cohort 1966 (NFBC1966). Methods: The study included individuals from the Northern Finland Birth Cohort 1966 (NFBC1966) who had available data for adiposity measures (body mass index and waist-to-hip ratio), alexithymia (measured by the 20-Item Toronto Alexithymia Scale: TAS-20), depressive symptoms (measured by the 13-item depression subscale of Hopkins Symptom Checklist: HSCL-13) at age of 31 years (n = 4773) and 46 years (n = 4431). Pearson's (r) correlation, and multiple linear regression were used to investigate the relationships between alexithymia, depressive symptoms, and adiposity measures. The potential mediating role of depressive symptoms was examined via Hayes' procedure (PROCESS). Results: Positive correlations were confirmed between adiposity measures (BMI and WHR) and the TAS-20 score (and its subscale), but not between obesity and HSCL-13 score. The strongest correlation was between the DIF (difficulty identifying feelings) subscale of the TAS-20 and HSCL-13 at both time points (31 y: r(3013) = 0.41, p < 0.01, 46 y: r(3013) = 0.43, p < 0.01). Depressive symptoms completely (z = 2.55 (±0.00003), p = 0.01) and partly (z = 2.16 (±0.0001), p = 0.03) mediated the alexithymia-obesity relationship over the 15-year time-period. Limitations: Other psychological and environmental factors such as interoception, dietary intake and physical activities may also play a role as a potential mediating factor in alexithymia-obesity relationship. Conclusions: Our findings provide additional insights of theoretical framework of depressive symptoms mediation effect in the relationship between alexithymia and obesity. Alexithymia and depression should, therefore, be considered in the design of future clinical obesity research. | en_US |
dc.description.sponsorship | NFBC1966 31 years follow up received financial support from University of Oulu Grant no. 65354, Oulu University Hospital Grant nos. 2/97, 8/97, Ministry of Health and Social Affairs Grant no. 23/251/97, 160/97, 190/97, National Institute for Health and Welfare, Helsinki Grant no. 54121, Regional Institute of Occupational Health, Oulu, Finland Grant nos. 50621, 54231. NFBC1966 46-year follow-up received financial support from University of Oulu2 Grant no. 24000692, Oulu University Hospital2 Grant no. 24301140, ERDF European Regional Development Fund Grant no. 539/2010 A31592. The first author, NHR, was funded by MARA [Majlis Amanah Rakyat] for her PhD study. SS, AIB, LAM, SKK, JM and MRJ have received funding from the DynaHEALTH European Union's Horizon 2020 research and innovation programme under grant agreement [No 633595]. | en_US |
dc.format.extent | 1 - 7 | - |
dc.format.medium | Print-Electronic | - |
dc.language | en | - |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Copyright © 2023 Elsevier B.V. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/j.jad.2023.03.026, made available on this repository under a Creative Commons CC BY-NC-ND attribution licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Alexithymia | en_US |
dc.subject | depressive symptoms | en_US |
dc.subject | depression | en_US |
dc.subject | mediation | en_US |
dc.subject | adiposity | en_US |
dc.subject | obesity | en_US |
dc.subject | body mass index | en_US |
dc.subject | waist-hip ratio | en_US |
dc.title | Depression mediates the relationship between alexithymia and obesity in the Northern Finland Birth Cohort 1966 (NFBC1966) | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.jad.2023.03.026 | - |
dc.relation.isPartOf | Journal of Affective Disorders | - |
pubs.publication-status | Published | - |
pubs.volume | 331 | - |
dc.identifier.eissn | 1573-2517 | - |
dc.rights.holder | Elsevier B.V. | - |
Appears in Collections: | Dept of Life Sciences Embargoed Research Papers |
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