Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/24186
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yin, X | - |
dc.contributor.author | Ma, W | - |
dc.contributor.author | Tang, M | - |
dc.contributor.author | Guo, J | - |
dc.date.accessioned | 2022-02-26T10:29:14Z | - |
dc.date.available | 2007-12-20 | - |
dc.date.available | 2022-02-26T10:29:14Z | - |
dc.date.issued | 2007-12-20 | - |
dc.identifier | 85 | - |
dc.identifier.citation | Yin, X., Ma, W., Tang, M. and Guo, J. (2007) 'Testing for homogeneity of gametic disequilibrium across strata', BMC Genetics 8, 85, pp. 1-14. doi.org: 10.1186/1471-2156-8-85. | en_US |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/24186 | - |
dc.description.abstract | Copyright © 2007 Yin et al. Background: Assessing the non-random associations of alleles at different loci, or gametic disequilibrium, can provide clues about aspects of population histories and mating behavior and can be useful in locating disease genes. For gametic data which are available from several strata with different allele probabilities, it is necessary to verify that the strata are homogeneous in terms of gametic disequilibrium. Results: Using the likelihood score theory generalized to nuisance parameters we derive a score test for homogeneity of gametic disequilibrium across several independent populations. Simulation results demonstrate that the empirical type I error rates of our score homogeneity test perform satisfactorily in the sense that they are close to the pre-chosen 0.05 nominal level. The associated power and sample size formulae are derived. We illustrate our test with a data set from a study of the cystic fibrosis transmembrane conductance regulator gene. Conclusion: We propose a large-sample homogeneity test on gametic disequilibrium across several independent populations based on the likelihood score theory generalized to nuisance parameters. Our simulation results show that our test is more reliable than the traditional test based on the Fisher's test of homogeneity among correlation coefficients. © 2007 Yin et al; licensee BioMed Central Ltd. | en_US |
dc.description.sponsorship | This research was supported by the National Natural Science Foundation of China (Grant Numbers 10431010 and 10701022), National 973 Key Project of China (2007CB311002), NCET-04-0310, EYTP, the Jilin Distinguished Young Scholars Program (Grant Number 20030113) and the Program Innovative Research Team (PCSIRT) in University (#IRT0519). The work of ML Tang was fully supported by a grant from the Research Grant Council of the Hong Kong Special Administration (Project no. HKBU261007). | en_US |
dc.format.extent | 1 - 14 | - |
dc.format.medium | Electronic | - |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dc.rights | Rights and permissions: copyright © 2007 Yin et al; licensee BioMed Central Ltd. Open Access. This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.rights.uri | https://creativecommons.org/licenses/by/2.0 | - |
dc.subject | cystic fibrosis transmembrane conductance regulator | en_US |
dc.subject | nuisance parameter | en_US |
dc.subject | homogeneity test | en_US |
dc.subject | nominal level | en_US |
dc.subject | empirical size | en_US |
dc.title | Testing for homogeneity of gametic disequilibrium across strata | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1186/1471-2156-8-85 | - |
dc.relation.isPartOf | BMC Genetics | - |
pubs.publication-status | Published | - |
pubs.volume | 8 | - |
dc.identifier.eissn | 1471-2156 | - |
Appears in Collections: | Dept of Mathematics Research Papers |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FullText.pdf | 315.57 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License