Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/24077
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dc.contributor.authorClare, L-
dc.contributor.authorGamble, L-
dc.contributor.authorMartyr, A-
dc.contributor.authorSabatini, S-
dc.contributor.authorNelis, S-
dc.contributor.authorQuinn, C-
dc.contributor.authorPentecost, C-
dc.contributor.authorVictor, C-
dc.contributor.authorJones, R-
dc.contributor.authorJones, I-
dc.contributor.authorKnapp, M-
dc.contributor.authorlitherland, R-
dc.contributor.authorMorris, R-
dc.contributor.authorRustead, J-
dc.contributor.authorThom, J-
dc.contributor.authorCollins, R-
dc.contributor.authorHenderson, C-
dc.contributor.authorMatthews, F-
dc.date.accessioned2022-02-08T10:47:15Z-
dc.date.available2022-02-08T10:47:15Z-
dc.date.issued2022-02-03-
dc.identifiergbac022-
dc.identifierORCID iD: Christina Victor: https://orcid.org/0000-0002-4213-3974-
dc.identifier.citationClare, L., Gamble, L.D., Martyr, A., Sabatini, S.,, Nelis, S.M., Quinn, C., Pentecost, C,, Victor, C.,, Jones, R.W., Jones, I.R., Knapp, M., Litherland, R., Morris, R.G.,, Rusted, J.M., Thom, J.M., Collins, R., Henderson, C., Matthews, F.E. and IDEAL study team (2022) 'Longitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study data', The Journals of Gerontology: Series B, 77 (6), gbac022, pp. 1037 - 1050 (14). doi: 10.1093/geronb/gbac022.en_US
dc.identifier.issn1079-5014-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/24077-
dc.descriptionSupplementary Material: Supplementary data are available at The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences online.-
dc.description.abstractCopyright © The Author(s) 2022. Objectives We aimed to examine change over time in self-rated quality of life (QoL) in people with mild-to-moderate dementia and identify sub-groups with distinct QoL trajectories. Method We used data from people with mild-to-moderate dementia followed up at 12 and 24 months in the IDEAL cohort study (baseline n=1537). A latent growth model approach examined mean change over time in QoL, assessed with the QoL-AD scale, and investigated associations of baseline demographic, cognitive and psychological covariates with the intercept and slope of QoL. We employed growth mixture modelling to identify multiple growth trajectories. Results Overall mean QoL scores were stable and no associations with change over time were observed. Four classes of QoL trajectories were identified: two with higher baseline QoL scores, labelled Stable (74.9%) and Declining (7.6%), and two with lower baseline QoL scores, labelled Stable Lower (13.7%) and Improving (3.8%). The Declining class had higher baseline levels of depression and loneliness, and lower levels of self-esteem and optimism, than the Stable class. The Stable Lower class was characterised by disadvantage related to social structure, poor physical health, functional disability, and low psychological well-being. The Improving class was similar to the Stable Lower class but had lower cognitive test scores. Discussion Understanding individual trajectories can contribute to personalised care planning. Efforts to prevent decline in perceived QoL should primarily target psychological well-being. Efforts to improve QoL for those with poorer QoL should additionally address functional impairment, isolation, and disadvantage related to social structure.en_US
dc.description.sponsorshipy Economic and Social Research Council (ESRC, part of UK Research and Innovation, UKRI) and National Institute for Health Research (NIHR) grant ES/L001853/2; Alzheimer’s Society Centre of Excellence grant 348, AS-PR2-16-001;en_US
dc.format.extent1037 - 1050 (14)-
dc.language.isoen_USen_US
dc.rightsCopyright © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectAlzheimer’sen_US
dc.subjectcaregiversen_US
dc.subjectlongitudinalen_US
dc.titleLongitudinal trajectories of quality of life among people with mild-to-moderate dementia: a latent growth model approach with IDEAL cohort study dataen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1093/geronb/gbac022-
dc.relation.isPartOfJournals of Gerontology, Series B-
pubs.issue6-
pubs.publication-statusPublished-
pubs.volume77-
dc.identifier.eissn1758-5368-
dc.rights.holderThe Author(s)-
Appears in Collections:Dept of Health Sciences Research Papers

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