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Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/24026
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dc.contributor.authorEtienne-Manneville, S-
dc.contributor.authorManneville, J-B-
dc.contributor.authorNicholls, S-
dc.contributor.authorFerenczi, MA-
dc.contributor.authorHall, A-
dc.date.accessioned2022-01-29T16:26:55Z-
dc.date.available2022-01-29T16:26:55Z-
dc.date.issued2005-09-12-
dc.identifier.citationEtienne-Manneville, S., Manneville, J.-B., Nicholls, S., Ferenczi, M.A. and Hall, A. (2005) 'Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization', Journal of Cell Biology, 170 (6), pp. 895 - 901. doi: 10.1083/jcb.200412172.en_US
dc.identifier.issn0021-9525-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/24026-
dc.description.abstractCopyright 2005 The Author(s) and Rockefeller University Press. Cell polarization is essential in a wide range of biological processes such as morphogenesis, asymmetric division, and directed migration. In this study, we show that two tumor suppressor proteins, adenomatous polyposis coli (APC) and Dlg1-SAP97, are required for the polarization of migrating astrocytes. Activation of the Par6–PKCζ complex by Cdc42 at the leading edge of migrating cells promotes both the localized association of APC with microtubule plus ends and the assembly of Dlg-containing puncta in the plasma membrane. Biochemical analysis and total internal reflection fluorescence microscopy reveal that the subsequent physical interaction between APC and Dlg1 is required for polarization of the microtubule cytoskeleton.en_US
dc.description.sponsorshipThis work was supported by a Marie Curie Individual Fellowship (to J.-B. Manneville), a Centre National de la Recherche Scientifique grant (to S. Eti- enne-Manneville), a Cancer Research UK program grant (to A. Hall), and the Medical Research Council.-
dc.format.extent895 - 901-
dc.format.mediumPrint-Electronic-
dc.languageEnglish-
dc.language.isoen_USen_US
dc.publisherRockefeller University Pressen_US
dc.rightsCopyright © 2005 Etienne-Manneville et al, and The Rockefeller University Press. Originally published in Journal of Cell Biology. https://doi.org/10.1083/jcb.200412172 In any of the following circumstances, you can use our content gratis (with appropriate attribution): If you are one of the original authors (in which case you retain copyright). If the article was published under a Creative Commons Attribution 4.0 International License (CC-BY). (To check if this was the case, see the first page of the PDF or very bottom of the HTML version of the article.) In your dissertation or doctoral thesis. In an educational setting where it will not be sold for profit. In an academic website or newsletter to promote your faculty’s research.-
dc.titleCdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarizationen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1083/jcb.200412172-
dc.relation.isPartOfJournal of Cell Biology-
pubs.issue6-
pubs.publication-statusPublished-
pubs.volume170-
dc.identifier.eissn1540-8140-
Appears in Collections:Dept of Health Sciences Research Papers

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