Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/20299
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DC Field | Value | Language |
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dc.contributor.author | Gao, Y | - |
dc.contributor.author | Xu, C | - |
dc.contributor.author | Yang, L | - |
dc.contributor.author | Wang, B | - |
dc.date.accessioned | 2020-02-14T14:17:57Z | - |
dc.date.available | 2019-12-01 | - |
dc.date.available | 2020-02-14T14:17:57Z | - |
dc.date.issued | 2019-12-01 | - |
dc.identifier.citation | International Journal of Simulation Modelling, 2019, 18 (4), pp. 643 - 653 | en_US |
dc.identifier.issn | 1726-4529 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/20299 | - |
dc.description.abstract | © 2019, DAAAM International Vienna. All rights reserved. A novel controlled drug delivery system was proposed, which contains a micro-structure for drug loading fabricated by using Poly(lactic-co-glycolic acid) (PLGA) via the hot-pressing method. The integrity of the PLGA micro-structure is the basis of the drug release control, but the visco-elastic property of PLGA causes the incomplete formation in the hot-pressing process. To obtain the improved hot-pressing parameters, the hot-pressing model of PLGA materials was established by using a 5-unit generalized Maxwell model. The influence of different hot-pressing parameters on the forming quality was studied. Simulation results show that the PLGA micro-structure was completely formed at the temperature of 75 °C, 1 mm base thickness, 30 N pressure, and 150 s maintenance time. The simulation results were validated by the hot-pressing fabrication. This study could lead theoretical basis for the preparation of visco-elastic polymer micro-structure by using the hot-pressing method and lay a foundation for the further optimization of hot-pressing process parameters. | en_US |
dc.description.sponsorship | National Natural Science Foundation of China; Basic Research Plan of Natural Science of Shaanxi Province | en_US |
dc.format.extent | 643 - 653 | - |
dc.language.iso | en | en_US |
dc.publisher | DAAAM Int. | en_US |
dc.subject | Visco-elastic property | en_US |
dc.subject | PLGA Micro-structure | en_US |
dc.subject | Hot-pressing method | en_US |
dc.subject | Process parameters | en_US |
dc.title | Simulation study on the formation of plga micro-structure using hot-pressing method | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.2507/IJSIMM18(4)496 | - |
dc.relation.isPartOf | International Journal of Simulation Modelling | - |
pubs.issue | 4 | - |
pubs.publication-status | Published | - |
pubs.volume | 18 | - |
dc.identifier.eissn | 1996-8566 | - |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Research Papers |
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FullText.pdf | 1.2 MB | Adobe PDF | View/Open |
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