1. Brunel University Research Archive
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  4. Dept of Mechanical and Aerospace Engineering Research Papers
Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/20231
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dc.contributor.authorDavies, G-
dc.contributor.authorLam, M-
dc.contributor.authorHarris, SE-
dc.contributor.authorTrampush, JW-
dc.contributor.authorLuciano, M-
dc.contributor.authorHill, WD-
dc.contributor.authorHagenaars, SP-
dc.contributor.authorRitchie, SJ-
dc.contributor.authorMarioni, RE-
dc.contributor.authorFawns-Ritchie, C-
dc.contributor.authorLiewald, DCM-
dc.contributor.authorOkely, JA-
dc.contributor.authorAhola-Olli, AV-
dc.contributor.authorBarnes, CLK-
dc.contributor.authorBertram, L-
dc.contributor.authorBis, JC-
dc.contributor.authorBurdick, KE-
dc.contributor.authorChristoforou, A-
dc.contributor.authorDerosse, P-
dc.contributor.authorDjurovic, S-
dc.contributor.authorEspeseth, T-
dc.contributor.authorGiakoumaki, S-
dc.contributor.authorGiddaluru, S-
dc.contributor.authorGustavson, DE-
dc.contributor.authorHayward, C-
dc.contributor.authorHofer, E-
dc.contributor.authorIkram, MA-
dc.contributor.authorKarlsson, R-
dc.contributor.authorKnowles, E-
dc.contributor.authorLahti, J-
dc.contributor.authorLeber, M-
dc.contributor.authorLi, S-
dc.contributor.authorMather, KA-
dc.contributor.authorMelle, I-
dc.contributor.authorMorris, D-
dc.contributor.authorOldmeadow, C-
dc.contributor.authorPalviainen, T-
dc.contributor.authorPayton, A-
dc.contributor.authorPazoki, R-
dc.contributor.authorPetrovic, K-
dc.contributor.authorReynolds, CA-
dc.contributor.authorSargurupremraj, M-
dc.contributor.authorScholz, M-
dc.contributor.authorSmith, JA-
dc.contributor.authorSmith, AV-
dc.contributor.authorTerzikhan, N-
dc.contributor.authorThalamuthu, A-
dc.contributor.authorTrompet, S-
dc.contributor.authorVan Der Lee, SJ-
dc.contributor.authorWare, EB-
dc.contributor.authorWindham, BG-
dc.contributor.authorWright, MJ-
dc.contributor.authorYang, J-
dc.contributor.authorYu, J-
dc.contributor.authorAmes, D-
dc.contributor.authorAmin, N-
dc.contributor.authorAmouyel, P-
dc.contributor.authorAndreassen, OA-
dc.contributor.authorArmstrong, NJ-
dc.contributor.authorAssareh, AA-
dc.contributor.authorAttia, JR-
dc.contributor.authorAttix, D-
dc.contributor.authorAvramopoulos, D-
dc.contributor.authorBennett, DA-
dc.contributor.authorBöhmer, AC-
dc.contributor.authorBoyle, PA-
dc.contributor.authorBrodaty, H-
dc.contributor.authorCampbell, H-
dc.contributor.authorCannon, TD-
dc.contributor.authorCirulli, ET-
dc.contributor.authorCongdon, E-
dc.contributor.authorConley, ED-
dc.contributor.authorCorley, J-
dc.contributor.authorCox, SR-
dc.contributor.authorDale, AM-
dc.contributor.authorDehghan, A-
dc.contributor.authorDick, D-
dc.contributor.authorDickinson, D-
dc.contributor.authorEriksson, JG-
dc.contributor.authorEvangelou, E-
dc.contributor.authorFaul, JD-
dc.contributor.authorFord, I-
dc.contributor.authorFreimer, NA-
dc.contributor.authorGao, H-
dc.contributor.authorGiegling, I-
dc.contributor.authorGillespie, NA-
dc.contributor.authorGordon, SD-
dc.contributor.authorGottesman, RF-
dc.contributor.authorGriswold, ME-
dc.contributor.authorGudnason, V-
dc.contributor.authorHarris, TB-
dc.contributor.authorHartmann, AM-
dc.contributor.authorHatzimanolis, A-
dc.contributor.authorHeiss, G-
dc.contributor.authorHolliday, EG-
dc.contributor.authorJoshi, PK-
dc.contributor.authorKähönen, M-
dc.contributor.authorKardia, SLR-
dc.contributor.authorKarlsson, I-
dc.contributor.authorKleineidam, L-
dc.date.accessioned2020-02-07T14:25:51Z-
dc.date.available2018-12-01-
dc.date.available2020-02-07T14:25:51Z-
dc.date.issued2018-05-29-
dc.identifier.citationNature Communications, 2018, 9 (1)en_US
dc.identifier.issnhttp://dx.doi.org/10.1038/s41467-018-04362-x-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/20231-
dc.description.abstractGeneral cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.en_US
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.titleStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive functionen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1038/s41467-018-04362-x-
dc.relation.isPartOfNature Communications-
pubs.issue1-
pubs.publication-statusPublished-
pubs.volume9-
dc.identifier.eissn2041-1723-
Appears in Collections:Dept of Mechanical and Aerospace Engineering Research Papers

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