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http://bura.brunel.ac.uk/handle/2438/16311
Title: | Non-invasive technique for determining local pulse wave velocity in humans ascending aorta |
Authors: | Negoita, M Hughes, AD Parker, KH Khir, AW |
Issue Date: | 2017 |
Publisher: | IEEE |
Citation: | Negoita, M., Hughes, A.D., Parker, K.H. and Khir, A.W. (2017) 'Non-invasive technique for determining local pulse wave velocity in humans ascending aorta', Computing in Cardiology, 2017, 44 pp. 1 - 4 |
Abstract: | Background: Pulse wave velocity (PWV) is a measure of arterial stiffness and widely used as a predictor of cardiovascular risk. Local PWV (lPWV) can be calculated non-invasively using the ln(D)U-loop method. Aim: To develop a novel non-invasive technique for the determination of lPWV in human ascending aorta. Methods: 13 healthy volunteers (19-33 years, 6 females) were studied using ultrasound (GE, Vivid E95) with a 1.5–4.5 MHz phased array transducer. M-mode in the parasternal long axis view was used for diameter measurements, Pulsed Wave Doppler ultrasound in the apical 5 chamber view was used for blood velocity measurements in the ascending aorta. Diameter and flow were measured sequentially. The ln(D)U-loop method was used to determine -lPWV, and the SphygmoCor Xcel (AtCor Medical, Australia) was used to measure carotid-femoral PWV (cfPWV). Results: Mean lPWV using ln(D)U-loop was 3.6±0.7 m/s with higher values for men compared to women. The results showed that lPWV was systematically lower than cfPWV. Conclusions: lPWV can be measured non-invasively at the ascending aorta by ultrasound with sequential recordings of diameter and velocity using the ln(D)U-loop method. |
URI: | https://bura.brunel.ac.uk/handle/2438/16311 |
DOI: | https://doi.org/10.22489/CinC.2017.218-036 |
ISSN: | 2325-8861 |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Research Papers |
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