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DC Field | Value | Language |
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dc.contributor.author | Zeka, A | - |
dc.contributor.author | Sullivan, JR | - |
dc.contributor.author | Vokonas, PS | - |
dc.contributor.author | Sparrow, D | - |
dc.contributor.author | Schwartz, J | - |
dc.date.accessioned | 2017-09-22T14:24:30Z | - |
dc.date.available | 2006 | - |
dc.date.available | 2017-09-22T14:24:30Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | International Journal of Epidemiology, 2006, 35 (5), pp. 1347 - 1354 | en_US |
dc.identifier.issn | 0300-5771 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/15188 | - |
dc.description.abstract | Background Increased concentrations of particles in air have been related to changes in inflammatory markers that in turn are hypothesized in mediating the particle effects on cardiovascular disease. The present work examined this association in an elderly cohort in the Greater Boston area and addresses the relative role of particles from different sources. Methods The study included 710 subjects, active members of the VA Normative Aging Study cohort with measurements of blood markers. Concentrations of particle number (PN), black carbon (BC), fine particulate matter (PM2.5), and sulphates were measured at a central site near the examination site. Results Positive associations were found between traffic-related particles (PN and BC) and inflammatory markers, but only suggestive associations were found with exposures to PM2.5 and sulphates. The particle effect on the inflammatory markers was greater among subjects older than 78 years and among obese. A suggestion for a greater effect of particles on inflammatory markers among GSTM1-null subjects and non-users of statin drugs was also seen. Conclusions The findings of the study support the hypothesis that particles can induce cardiovascular disease through inflammatory pathways, suggestive of a greater toxicity of traffic-related particles. | en_US |
dc.description.sponsorship | Supported by the Harvard Environmental Protection Agency (EPA) PM Center, Grant R827353. The VA Normative Aging Study (NAS) is supported by the Cooperative Studies Program/ ERIC of the US Department of Veterans Affairs and is a component of the Massachusetts Veterans Epidemiology Research and Informative Center (MAVERIC), Boston, MA. We wish to thank Elaine R Dibbs and Jordan D Awerbach for their invaluable assistance in conducting the laboratory measurements. | en_US |
dc.format.extent | 1347 - 1354 | - |
dc.language | EN | - |
dc.language.iso | en | en_US |
dc.subject | Air pollution | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | blood sedimentation | en_US |
dc.subject | fibrinogen | en_US |
dc.subject | inflammation | en_US |
dc.subject | sulphates | en_US |
dc.subject | white blood cells | en_US |
dc.title | Inflammatory markers and particulate air pollution: characterizing the pathway to disease | en_US |
dc.type | Article | en_US |
dc.identifier.doi | http://dx.doi.org/10.1093/ije/dyl132 | - |
dc.relation.isPartOf | International Journal of Epidemiology | - |
pubs.issue | 5 | - |
pubs.volume | 35 | - |
Appears in Collections: | Dept of Mechanical and Aerospace Engineering Research Papers |
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