Please use this identifier to cite or link to this item:
Title: Combined exposure to low doses of pesticides causes decreased birth weights in rats
Authors: Hass, U
Christiansen, S
Axelstad, M
Scholze, M
Boberg, J
Keywords: Cyromazine;MCPB;Pirimicarb;Quinoclamine;Thiram;Ziram;Mixture;Birth weight;Pesticides;Additivity;Rat
Issue Date: 2017
Citation: Reproductive Toxicology, 2017
Abstract: © 2017.Decreased birth weight is a common effect of many pesticides in reproductive toxicity studies, but there are no empirical data on how pesticides act in combination on this endpoint. We hypothesized that a mixture of six pesticides (cyromazine, MCPB, pirimicarb, quinoclamine, thiram, and ziram) would decrease birth weight, and that these mixture effects could be predicted by the Dose Addition model. Data for the predictions were obtained from the Draft Assessment Reports of the individual pesticides. A mixture of equi-effective doses of these pesticides was tested in two studies in Wistar rats, showing mixture effects in good agreement with the additivity predictions. Significantly lower birth weights were observed when compounds were present at individual doses below their no-observed adverse effect levels (NOAELs). These results emphasize the need for cumulative risk assessment of pesticides to avoid potentially serious impact of mixed exposure on prenatal development and pregnancy in humans.
ISSN: 0890-6238
Appears in Collections:Publications

Files in This Item:
File Description SizeFormat 
FullText.pdfFile embargoed until 17/05/2018337.16 kBAdobe PDFView/Open

Items in BURA are protected by copyright, with all rights reserved, unless otherwise indicated.