Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/14649
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dc.contributor.authorBradfield, JP-
dc.contributor.authorTaal, HR-
dc.contributor.authorTimpson, NJ-
dc.contributor.authorScherag, A-
dc.contributor.authorLecoeur, C-
dc.contributor.authorWarrington, NM-
dc.contributor.authorHypponen, E-
dc.contributor.authorHolst, C-
dc.contributor.authorValcarcel, B-
dc.contributor.authorThiering, E-
dc.contributor.authorSalem, RM-
dc.contributor.authorSchumacher, FR-
dc.contributor.authorCousminer, DL-
dc.contributor.authorSleiman, PMA-
dc.contributor.authorZhao, J-
dc.contributor.authorBerkowitz, RI-
dc.contributor.authorVimaleswaran, KS-
dc.contributor.authorJarick, I-
dc.contributor.authorPennell, CE-
dc.contributor.authorEvans, DM-
dc.contributor.authorSt Pourcain, B-
dc.contributor.authorBerry, DJ-
dc.contributor.authorMook-Kanamori, DO-
dc.contributor.authorHofman, A-
dc.contributor.authorRivadeneira, F-
dc.contributor.authorUitterlinden, AG-
dc.contributor.authorvan Duijn, CM-
dc.contributor.authorvan der Valk, RJP-
dc.contributor.authorde Jongste, JC-
dc.contributor.authorPostma, DS-
dc.contributor.authorBoomsma, DI-
dc.contributor.authorGauderman, WJ-
dc.contributor.authorHassanein, MT-
dc.contributor.authorLindgren, CM-
dc.contributor.authorMagi, R-
dc.contributor.authorBoreham, CAG-
dc.contributor.authorNeville, CE-
dc.contributor.authorMoreno, LA-
dc.contributor.authorElliott, P-
dc.contributor.authorPouta, A-
dc.contributor.authorHartikainen, A-L-
dc.contributor.authorLi, M-
dc.contributor.authorRaitakari, O-
dc.contributor.authorLehtimaki, T-
dc.contributor.authorEriksson, JG-
dc.contributor.authorPalotie, A-
dc.contributor.authorDallongeville, J-
dc.contributor.authorDas, S-
dc.contributor.authorDeloukas, P-
dc.contributor.authorMcMahon, G-
dc.contributor.authorRing, SM-
dc.contributor.authorKemp, JP-
dc.contributor.authorBuxton, JL-
dc.contributor.authorBlakemore, AIF-
dc.contributor.authorBustamante, M-
dc.contributor.authorGuxens, M-
dc.contributor.authorHirschhorn, JN-
dc.contributor.authorGillman, MW-
dc.contributor.authorKreiner-Moller, E-
dc.contributor.authorBisgaard, H-
dc.contributor.authorGilliland, FD-
dc.contributor.authorHeinrich, J-
dc.contributor.authorWheeler, E-
dc.contributor.authorBarroso, I-
dc.contributor.authorO'Rahilly, S-
dc.contributor.authorMeirhaeghe, A-
dc.contributor.authorSorensen, TIA-
dc.contributor.authorPower, C-
dc.contributor.authorPalmer, LJ-
dc.contributor.authorHinney, A-
dc.contributor.authorWiden, E-
dc.contributor.authorFarooqi, IS-
dc.contributor.authorMcCarthy, MI-
dc.contributor.authorFroguel, P-
dc.contributor.authorMeyre, D-
dc.contributor.authorHebebrand, J-
dc.contributor.authorJarvelin, M-R-
dc.contributor.authorJaddoe, VWV-
dc.contributor.authorSmith, GD-
dc.contributor.authorHakonarson, H-
dc.contributor.authorGrant, SFA-
dc.date.accessioned2017-06-01T11:08:51Z-
dc.date.available2012-05-01-
dc.date.available2017-06-01T11:08:51Z-
dc.date.issued2012-
dc.identifier.citationNature Genetics, 44(5): pp. 526 - 531, (2012)en_US
dc.identifier.issn1061-4036-
dc.identifier.urihttp://bura.brunel.ac.uk/handle/2438/14649-
dc.description.abstractMultiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1.en_US
dc.format.extent526 - + (7)-
dc.languageEnglish-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectBody-mass indexen_US
dc.subjectHelicobacter-pylorien_US
dc.subjectDisease geneticsen_US
dc.subjectGenome-wide association studiesen_US
dc.subjectObesityen_US
dc.titleA genome-wide association meta-analysis identifies new childhood obesity locien_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1038/ng.2247-
dc.relation.isPartOfNATURE GENETICS-
pubs.issue5-
pubs.publication-statusPublished-
pubs.volume44-
Appears in Collections:Dept of Life Sciences Research Papers

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