Please use this identifier to cite or link to this item: http://bura.brunel.ac.uk/handle/2438/14557
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dc.contributor.authorBridger, JM-
dc.contributor.authorArican-Goktas, HD-
dc.contributor.authorJobling, S-
dc.contributor.authorAdema, CM-
dc.contributor.authorHillier, LW-
dc.contributor.authorJones, CS-
dc.contributor.authorLoker, ES-
dc.contributor.authorKnight, M-
dc.contributor.authorMinx, P-
dc.contributor.authorOliveira, G-
dc.contributor.authorRaghavan, N-
dc.contributor.authorShedlock, A-
dc.contributor.authorRodrigues do Amaral, L-
dc.contributor.authorAssis, JG-
dc.date.accessioned2017-05-17T13:37:08Z-
dc.date.available2017-05-16-
dc.date.available2017-05-17T13:37:08Z-
dc.date.issued2017-05-16-
dc.identifier.citationAdema, C., Hillier, L., Jones, C. et al. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun 8, 15451 (2017).en_US
dc.identifier.issn2041-1723-
dc.identifier.urihttps://bura.brunel.ac.uk/handle/2438/14557-
dc.description.abstractBiomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.en_US
dc.description.sponsorshipWe acknowledge access to the Metafer microscopy system at the I. Robinson Research Complex, Harwell, Rutherford Appleton Laboratory, Oxon, UK (BBSRC Professorial Fellowship, grant number BB/H022597/1). Sequence characterization of the Biomphalaria glabrata genome was funded by NIH-NHGRI grant HG003079 to R.K.W., McDonnell Genome Institute, Washington University School of Medicine. Biomphalaria glabrata and Schistosoma mansoni were provided to some participating labs by the NIAID Schistosomiasis Resource Center (Biomedical Research Institute, Rockville, MD) through NIH-NIAID Contract HHSN272201000005I for distribution through BEI Resources. C.M.A. and E.S.L. acknowledge NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). Publication costs were contributed equally by McDonnell Genome Institute, Washington University School of Medicine and the COBRE Center for Evolutionary and Theoretical Immunology (CETI) which is supported by NIH grant P30GM110907 from the National Institute of General Medical Sciences (NIGMS). E.S.L. acknowledges NIH/NIAID ROI AI101438. J.M.B., H.D.A.-G and M.K. acknowledge NIH-NIAID R01-AI0634808. M.Y. acknowledges UK BBSRC (BB/H022597/1). G.O. acknowledges support from FAPEMIG (RED-00014-14, PPM-00189-13) and CNPq (304138/2014-2, 309312/2012-4). R.L.C. acknowledges CNPq (503275/2011-5). T.P.Y. acknowledges NIH/NIAID RO1AI015503. K.F.H. and M.T.S. acknowledge BBSRC (BB/K005448/1). B.G. acknowledges ANR JCJC INVIMORY (ANR-13-JSV7-0009). S.E. acknowledges NIAID contract HHSN272201400029C. J.M.K. acknowledges the Research Council for Earth and Life Sciences (A.L.W.; 819.01.007) and the Netherlands Organization for Scientific Research (NWO). R.M.C. acknowledges NIH GM061738 and support from the American Heart Association, Southwest Affiliate (14GRNT20490250). D.T. acknowledges NIH R25 GM075149. C.F. acknowledges NIH R01-GM077582. D.J.J. acknowledges D.F.G. JA2108/1-2. M.de S.G. acknowledges CNPq 479890/2013-7. K.M.B. and J.P.R. acknowledge NSERC 312221 and CIHR MOP74667. C.S.J., L.R.N., S.J., E.J.R., S.K. and A.E.L. acknowledge NC3R GO900802/1. K.K.B. and K.B.S. acknowledge NSERC 315051 and 6793, respectively. M.B. and C.J.B. acknowledge NIH RO1-AI109134. C.J.B. acknowledges NIH AI016137 and AI111201. B.R. acknowledges NHGRI 4U41HG002371. P.C.H., M.A.G. and E.A.P. acknowledge NSERC 418540. O.L.B. and Ch.C. acknowledge ANR-12-EMMA-0007-01. S.F.C. acknowledges Australian Research Council FT110100990.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectDNA sequencing-
dc.subjectGenome-
dc.subjectGenome informatics-
dc.subjectZoology-
dc.titleWhole genome analysis of a schistosomiasis-transmitting freshwater snailen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1038/ncomms15451-
dc.relation.isPartOfNature Communications-
pubs.publication-statusPublished-
pubs.volume8-
Appears in Collections:Dept of Life Sciences Research Papers

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