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Title: | Whole genome analysis of a schistosomiasis-transmitting freshwater snail |
Authors: | Bridger, JM Arican-Goktas, HD Jobling, S Adema, CM Hillier, LW Jones, CS Loker, ES Knight, M Minx, P Oliveira, G Raghavan, N Shedlock, A Rodrigues do Amaral, L Assis, JG |
Keywords: | DNA sequencing;Genome;Genome informatics;Zoology |
Issue Date: | 16-May-2017 |
Publisher: | Nature Publishing Group |
Citation: | Adema, C., Hillier, L., Jones, C. et al. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun 8, 15451 (2017). |
Abstract: | Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis. |
URI: | https://bura.brunel.ac.uk/handle/2438/14557 |
DOI: | https://doi.org/10.1038/ncomms15451 |
ISSN: | 2041-1723 |
Appears in Collections: | Dept of Life Sciences Research Papers |
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