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DC Field | Value | Language |
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dc.contributor.advisor | Li, S | - |
dc.contributor.author | Omodho, Becky | - |
dc.date.accessioned | 2016-11-18T13:22:02Z | - |
dc.date.available | 2016-11-18T13:22:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://bura.brunel.ac.uk/handle/2438/13516 | - |
dc.description | This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London | en_US |
dc.description.abstract | This study investigated the role of tolerance induction in an inflammatory setting in regard to the early growth response genes Egr2 and Egr3. T cells robustly respond to pathogenic antigens during infection, but are tolerant to stimulation by self-antigens. The intrinsic mechanisms for self-tolerance in the periphery are still not clear. Egr2 and 3 are induced in tolerant T cells in response to antigen stimulation by NFAT-medicated tolerant signalling; however, their function in tolerant T cells is still unknown. The study demonstrated that Egr2 and 3, induced in tolerant T cells, are not directly involved in defective proliferation and IL-2 production, the hallmarks of T cell tolerance. However, they are essential for preventing inflammatory response of tolerant T cells. In the absence of Egr2 and 3, tolerant T cells show impaired proliferation and production of IL-2, but produce high levels of IFN-γ, a key inflammatory cytokine. This phenotype resembles CD4 T cells from autoimmune diseases such as lupus which show poor proliferative response, but hyper-inflammation. Our study demonstrated, for the first time, a distinctive mechanism to control inflammation from proliferative tolerance regulated by Egr2 and 3, which may be an important mechanism for the control of autoimmune diseases. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Brunel University London | en_US |
dc.subject | Anergy induction in-vitro | en_US |
dc.subject | Tolerance induction in-vivo | en_US |
dc.subject | Egr2/3 in tolerance induction | en_US |
dc.subject | T cell proliferative responses | en_US |
dc.subject | Transcription factor in tolerance | en_US |
dc.title | Early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells | en_US |
dc.type | Thesis | en_US |
Appears in Collections: | Biological Sciences Dept of Life Sciences Theses |
Files in This Item:
File | Description | Size | Format | |
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FulltextThesis.pdf | 6.32 MB | Adobe PDF | View/Open |
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