Please use this identifier to cite or link to this item:
http://bura.brunel.ac.uk/handle/2438/10457
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kolyva, C | - |
dc.contributor.author | Pantalos, GM | - |
dc.contributor.author | Pepper, JR | - |
dc.contributor.author | Khir, AW | - |
dc.date.accessioned | 2015-03-20T12:28:48Z | - |
dc.date.available | 2015-03-01 | - |
dc.date.available | 2015-03-20T12:28:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The International Journal of Artifical Organs, 38(3): pp. 146-153, (2015) | en_US |
dc.identifier.issn | 1724-6040 | - |
dc.identifier.uri | https://bura.brunel.ac.uk/handle/2438/10457 | - |
dc.description.abstract | PURPOSE: The intra-aortic balloon pump (IABP) provides circulatory support through counterpulsation. The hemodynamic effects of the IABP may vary with assisting frequency and depend on IAB inflation/deflation timing. We aimed to assess in vivo the IABP benefits on coronary, aortic, and left ventricular hemodynamics at different assistance frequencies and trigger timings. METHODS: Six healthy, anesthetized, open-chest sheep received IABP support at 5 timing modes (EC, LC, CC, CE, CL, corresponding to early/late/conventional/conventional/conventional inflation and conventional/conventional/conventional/early/late deflation, respectively) with frequency 1:3 and 1:1. Aortic (Qao) and coronary (Qcor) flow, and aortic (Pao) and left ventricular (PLV) pressure were recorded simultaneously, with and without IABP support. Integrating systolic Qao yielded stroke volume (SV). RESULTS: EC at 1:1 produced the lowest end-diastolic Pao (59.5 ± 7.8 mmHg [EC], 63.4 ± 11.1 mmHg [CC]), CC at 1:1 the lowest systolic PLV (69.1 ± 6.5 mmHg [CC], 76.4 ± 6.5 mmHg [control]), CC at 1:1 the highest SV (88.5 ± 34.4 ml [CC], 76.6 ± 31.9 ml [control]) and CC at 1:3 the highest diastolic Qcor (187.2 ± 25.0 ml/min [CC], 149.9 ± 16.6 ml/min [control]). Diastolic Pao augmentation was enhanced by both assistance frequencies alike, and optimal timings were EC for 1:3 (10.4 ± 2.8 mmHg [EC], 6.7 ± 3.8 mmHg [CC]) and CC for 1:1 (10.8 ± 6.7 mmHg [CC], -3.0 ± 3.8 mmHg [control]). CONCLUSIONS: In our experiments, neither a single frequency nor a single inflation/deflation timing, including conventional IAB timing, has shown superiority by uniformly benefiting all studied hemodynamic parameters. A choice of optimal frequency and IAB timing might need to be made based on individual patient hemodynamic needs rather than as a generalized protocol. | en_US |
dc.description.sponsorship | British Heart Foundation (PG/12/73/29730). | en_US |
dc.format.extent | 146 - 153 | - |
dc.language.iso | en | en_US |
dc.publisher | Wichtig Publishing | en_US |
dc.rights | This article is published by Wichtig Publishing and licensed under Creative Commons Attribution-NC-ND 4.0 International (CC BY-NC-ND 4.0). Any commercial use is not permitted and is subject to Publisher’s permissions. Full information is available at www.wichtig.com | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | intra-aortic balloon pump (IABP) | en_US |
dc.subject | circulatory support | en_US |
dc.subject | counterpulsation | en_US |
dc.subject | hemodynamic effects | en_US |
dc.subject | vivo | en_US |
dc.subject | assistance frequencies | en_US |
dc.subject | trigger timings | en_US |
dc.title | Does conventional intra-aortic balloon pump trigger timing produce optimal hemodynamic effects in vivo? | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.5301/ijao.5000385 | - |
dc.relation.isPartOf | Int J Artif Organs | - |
pubs.publication-status | Published | - |
pubs.organisational-data | /Brunel | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Mechanical, Aerospace and Civil Engineering | - |
pubs.organisational-data | /Brunel/Brunel Staff by College/Department/Division/College of Engineering, Design and Physical Sciences/Dept of Mechanical, Aerospace and Civil Engineering/Mechanical and Aerospace Engineering | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies | - |
pubs.organisational-data | /Brunel/Brunel Staff by Institute/Theme/Institute of Environmental, Health and Societies/Biomedical Engineering and Healthcare Technologies | - |
pubs.organisational-data | /Brunel/Specialist Centres | - |
pubs.organisational-data | /Brunel/Specialist Centres/BIB | - |
Appears in Collections: | Brunel Institute for Bioengineering (BIB) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Fulltext.pdf | 549.88 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License